MARCH5/Mfn2 Peptide Inhibitors: A Mitochondrial Therapeutic for CVDs

Nir Qvit

MARCH5/Mfn2 Peptide Inhibitors: A Mitochondrial Therapeutic for CVDs

Nir Qvit

Bar-Ilan University - Azrieli Faculty of Medicine

Research output: Contribution to conference › Abstract › peer-review

Abstract

Cardiovascular diseases, CVDs, remain a leading cause of mortality and morbidity worldwide, emphasizing the need
for innovative therapeutic strategies. Mitochondria play a pivotal role in cardiac health, acting as the primary energy
producers and regulators of key cellular functions. Mitochondrial dynamics, including fusion, fission, and mitophagy,
are essential for maintaining mitochondrial quality and function. Dysregulation of these processes has been impli
cated in the pathogenesis of CVDs, yet the molecular mechanisms underlying mitochondrial dysfunction in cardiac
diseases remain incompletely understood.

Original language	English
State	Published - 16 Jun 2025
Event	29th American Peptide Symposium - Duration: 15 Jun 2025 → 19 Jun 2025

Conference

Conference	29th American Peptide Symposium
Period	15/06/25 → 19/06/25

UN SDGs

This output contributes to the following UN Sustainable Development Goals (SDGs)

SDG 3 Good Health and Well-being

Cite this

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title = "MARCH5/Mfn2 Peptide Inhibitors: A Mitochondrial Therapeutic for CVDs",

abstract = "Cardiovascular diseases, CVDs, remain a leading cause of mortality and morbidity worldwide, emphasizing the need for innovative therapeutic strategies. Mitochondria play a pivotal role in cardiac health, acting as the primary energy producers and regulators of key cellular functions. Mitochondrial dynamics, including fusion, fission, and mitophagy, are essential for maintaining mitochondrial quality and function. Dysregulation of these processes has been impli cated in the pathogenesis of CVDs, yet the molecular mechanisms underlying mitochondrial dysfunction in cardiac diseases remain incompletely understood.",

author = "Nir Qvit",

year = "2025",

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language = "English",

note = "29th American Peptide Symposium ; Conference date: 15-06-2025 Through 19-06-2025",

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T1 - MARCH5/Mfn2 Peptide Inhibitors: A Mitochondrial Therapeutic for CVDs

AU - Qvit, Nir

PY - 2025/6/16

Y1 - 2025/6/16

N2 - Cardiovascular diseases, CVDs, remain a leading cause of mortality and morbidity worldwide, emphasizing the need for innovative therapeutic strategies. Mitochondria play a pivotal role in cardiac health, acting as the primary energy producers and regulators of key cellular functions. Mitochondrial dynamics, including fusion, fission, and mitophagy, are essential for maintaining mitochondrial quality and function. Dysregulation of these processes has been impli cated in the pathogenesis of CVDs, yet the molecular mechanisms underlying mitochondrial dysfunction in cardiac diseases remain incompletely understood.

AB - Cardiovascular diseases, CVDs, remain a leading cause of mortality and morbidity worldwide, emphasizing the need for innovative therapeutic strategies. Mitochondria play a pivotal role in cardiac health, acting as the primary energy producers and regulators of key cellular functions. Mitochondrial dynamics, including fusion, fission, and mitophagy, are essential for maintaining mitochondrial quality and function. Dysregulation of these processes has been impli cated in the pathogenesis of CVDs, yet the molecular mechanisms underlying mitochondrial dysfunction in cardiac diseases remain incompletely understood.

UR - http://10.183.193.215:8082/6ced8d3b-d9ff-4f31-979a-0647230ba9f4/16867405-1b5e-47f3-8035-6f50dfa1d075/ws/files/260866845/Qvit-APS.docx

M3 - Abstract

T2 - 29th American Peptide Symposium

Y2 - 15 June 2025 through 19 June 2025

ER -

MARCH5/Mfn2 Peptide Inhibitors: A Mitochondrial Therapeutic for CVDs

Abstract

Conference

UN SDGs

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