Maintaining Golgi Homeostasis: A Balancing Act of Two Proteolytic Pathways

Ron Benyair, Avital Eisenberg-Lerner, Yifat Merbl

Research output: Contribution to journalReview articlepeer-review


The Golgi apparatus is a central hub for cellular protein trafficking and signaling. Golgi structure and function is tightly coupled and undergoes dynamic changes in health and disease. A crucial requirement for maintaining Golgi homeostasis is the ability of the Golgi to target aberrant, misfolded, or otherwise unwanted proteins to degradation. Recent studies have revealed that the Golgi apparatus may degrade such proteins through autophagy, retrograde trafficking to the ER for ER-associated degradation (ERAD), and locally, through Golgi apparatus-related degradation (GARD). Here, we review recent discoveries in these mechanisms, highlighting the role of the Golgi in maintaining cellular homeostasis.
Original languageEnglish
Article number780
Number of pages17
JournalCells (Basel, Switzerland)
Issue number5
Early online date23 Feb 2022
StatePublished - Mar 2022


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