TY - JOUR
T1 - Maintaining Golgi Homeostasis: A Balancing Act of Two Proteolytic Pathways
AU - Benyair, Ron
AU - Eisenberg-Lerner, Avital
AU - Merbl, Yifat
N1 - Publisher Copyright: © 2022 by the authors. Licensee MDPI, Basel, Switzerland.
PY - 2022/3
Y1 - 2022/3
N2 - The Golgi apparatus is a central hub for cellular protein trafficking and signaling. Golgi structure and function is tightly coupled and undergoes dynamic changes in health and disease. A crucial requirement for maintaining Golgi homeostasis is the ability of the Golgi to target aberrant, misfolded, or otherwise unwanted proteins to degradation. Recent studies have revealed that the Golgi apparatus may degrade such proteins through autophagy, retrograde trafficking to the ER for ER-associated degradation (ERAD), and locally, through Golgi apparatus-related degradation (GARD). Here, we review recent discoveries in these mechanisms, highlighting the role of the Golgi in maintaining cellular homeostasis.
AB - The Golgi apparatus is a central hub for cellular protein trafficking and signaling. Golgi structure and function is tightly coupled and undergoes dynamic changes in health and disease. A crucial requirement for maintaining Golgi homeostasis is the ability of the Golgi to target aberrant, misfolded, or otherwise unwanted proteins to degradation. Recent studies have revealed that the Golgi apparatus may degrade such proteins through autophagy, retrograde trafficking to the ER for ER-associated degradation (ERAD), and locally, through Golgi apparatus-related degradation (GARD). Here, we review recent discoveries in these mechanisms, highlighting the role of the Golgi in maintaining cellular homeostasis.
UR - http://www.scopus.com/inward/record.url?scp=85125226894&partnerID=8YFLogxK
U2 - 10.3390/cells11050780
DO - 10.3390/cells11050780
M3 - مقالة مرجعية
C2 - 35269404
SN - 2073-4409
VL - 11
JO - Cells (Basel, Switzerland)
JF - Cells (Basel, Switzerland)
IS - 5
M1 - 780
ER -