Magnetically targeted endothelial cells for prevention of vascular restenosis

Boris Polyak, Mikhail Medved, Nina Lazareva, Lindsay Steele, Tirth Patel, Ahmad Rai, Menahem Y. Rotenberg, Kimberly Wasko, Andrew R. Kohut, Richard Sensenig, Gennady Friedman

Research output: Chapter in Book/Report/Conference proceedingConference contributionpeer-review

Abstract

The present study assessed the potential of magnetically mediated delivery of endothelial cells (ECs) to inhibit in-stent stenosis induced by mechanical injury in a rat carotid artery stent angioplasty model. Syngeneic ECs loaded with polymeric magnetic nanoparticles (MNPs) were administered at the distal end of the stented artery using a brief exposure (12 min) to a uniform magnetic field (1.4-kOe). After two months, magnetic localization of ECs demonstrated significant protection from stenosis at the distal part of the stent in the cell therapy group compared to both the proximal part of stent in the cell therapy group and the control (stented, nontreated) group: 1.7-fold (p < 0.001) less reduction in lumen diameter as measured by B-mode and color Doppler ultrasound, 2.3-fold (p < 0.001) less reduction in the ratios of peak systolic velocities as measured by pulsed wave Doppler ultrasound, and 2.1-fold (p < 0.001) attenuation of stenosis as determined through end point morphometric analysis.

Original languageEnglish
Title of host publicationBiotech, Biomaterials and Biomedical - TechConnect Briefs 2017
EditorsFiona Case, Matthew Laudon, Bart Romanowicz
Pages67-70
Number of pages4
ISBN (Electronic)9780998878201
StatePublished - 2017
Event11th Annual TechConnect World Innovation Conference and Expo, Held Jointly with the 20th Annual Nanotech Conference and Expo, and the 2017 National SBIR/STTR Conference - Washington, United States
Duration: 14 May 201717 May 2017

Publication series

NameAdvanced Materials - TechConnect Briefs 2017
Volume3

Conference

Conference11th Annual TechConnect World Innovation Conference and Expo, Held Jointly with the 20th Annual Nanotech Conference and Expo, and the 2017 National SBIR/STTR Conference
Country/TerritoryUnited States
CityWashington
Period14/05/1717/05/17

Keywords

  • Cell therapy
  • Endothelium
  • In-stent restenosis
  • Magnetic targeting
  • Vascular healing

All Science Journal Classification (ASJC) codes

  • Fuel Technology
  • Surfaces, Coatings and Films
  • Biotechnology
  • Fluid Flow and Transfer Processes

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