Magnetic nanoparticle-based approaches to locally target therapy and enhance tissue regeneration in vivo

Richard Sensenig; Yulia Sapir; Cristin MacDonald; Smadar Cohen; Boris Polyak

doi:10.2217/nnm.12.109

Magnetic nanoparticle-based approaches to locally target therapy and enhance tissue regeneration in vivo

Richard Sensenig, Yulia Sapir, Cristin MacDonald, Smadar Cohen, Boris Polyak

Department of Biotechnology Engineering

Ben-Gurion University of the Negev

Research output: Contribution to journal › Review article › peer-review

Abstract

Magnetic-based systems utilizing superparamagnetic nanoparticles and a magnetic field gradient to exert a force on these particles have been used in a wide range of biomedical applications. This review is focused on drug targeting applications that require penetration of a cellular barrier as well as strategies to improve the efficacy of targeting in these biomedical applications. Another focus of this review is regenerative applications utilizing tissue engineered scaffolds prepared with the aid of magnetic particles, the use of remote actuation for release of bioactive molecules and magneto-mechanical cell stimulation, cell seeding and cell patterning.

Original language	American English
Pages (from-to)	1425-1442
Number of pages	18
Journal	Nanomedicine
Volume	7
Issue number	9
DOIs	https://doi.org/10.2217/nnm.12.109
State	Published - 1 Sep 2012

Keywords

cell therapy
drug delivery
forced transport
magnetic cell seeding
magnetic cell stimulation
magnetic targeting
patterned cell assemblies
superparamagnetic nanoparticles
time-varied magnetic field
tissue engineering

All Science Journal Classification (ASJC) codes

Bioengineering
Medicine (miscellaneous)
Biomedical Engineering
General Materials Science
Development

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10.2217/nnm.12.109

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abstract = "Magnetic-based systems utilizing superparamagnetic nanoparticles and a magnetic field gradient to exert a force on these particles have been used in a wide range of biomedical applications. This review is focused on drug targeting applications that require penetration of a cellular barrier as well as strategies to improve the efficacy of targeting in these biomedical applications. Another focus of this review is regenerative applications utilizing tissue engineered scaffolds prepared with the aid of magnetic particles, the use of remote actuation for release of bioactive molecules and magneto-mechanical cell stimulation, cell seeding and cell patterning.",

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AU - Sapir, Yulia

AU - MacDonald, Cristin

AU - Cohen, Smadar

AU - Polyak, Boris

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AB - Magnetic-based systems utilizing superparamagnetic nanoparticles and a magnetic field gradient to exert a force on these particles have been used in a wide range of biomedical applications. This review is focused on drug targeting applications that require penetration of a cellular barrier as well as strategies to improve the efficacy of targeting in these biomedical applications. Another focus of this review is regenerative applications utilizing tissue engineered scaffolds prepared with the aid of magnetic particles, the use of remote actuation for release of bioactive molecules and magneto-mechanical cell stimulation, cell seeding and cell patterning.

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KW - drug delivery

KW - forced transport

KW - magnetic cell seeding

KW - magnetic cell stimulation

KW - magnetic targeting

KW - patterned cell assemblies

KW - superparamagnetic nanoparticles

KW - time-varied magnetic field

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M3 - Review article

SN - 1743-5889

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EP - 1442

JO - Nanomedicine

JF - Nanomedicine

IS - 9

ER -

Magnetic nanoparticle-based approaches to locally target therapy and enhance tissue regeneration in vivo

Abstract

Keywords

All Science Journal Classification (ASJC) codes

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