Magnetic and Gold Nanoparticles Optimized for Cancer Treatment via Cell Hitchhiking

M. N. Yakovtseva; O. Betzer; A. V. Lunin; E. N. Mochalova; M. Beiderman; M. Motiei; S. D. Zvereva; O. B. Proushinskaya; T. Sadan; R. Popovtzer; M. P. Nikitin

doi:10.1109/ICLO48556.2020.9285858

Magnetic and Gold Nanoparticles Optimized for Cancer Treatment via Cell Hitchhiking

M. N. Yakovtseva, O. Betzer, A. V. Lunin, E. N. Mochalova, M. Beiderman, M. Motiei, S. D. Zvereva, O. B. Proushinskaya, T. Sadan, R. Popovtzer, M. P. Nikitin

Research output: Chapter in Book/Report/Conference proceeding › Conference contribution › peer-review

Abstract

To date, targeting cancer cells by nanoparticles has been limited due to physical and biological obstructions, including the mononuclear phagocyte system. A novel approach for prolongation of nanoparticle circulation is cellular 'hitchhiking', or use of cells as vehicles to increase co-delivery of cancer therapeutics and particles to affected tissue. In this work, we studied the main characteristics of nanoagents based on magnetic and gold particles, to ensure optimal physicochemical characteristics. The developed agents hold promise to overcome the challenges that still hinder effective drug delivery for treatment of such complex diseases as cancer.

Original language	English
Title of host publication	Proceedings - International Conference Laser Optics 2020, ICLO 2020
Publisher	Institute of Electrical and Electronics Engineers Inc.
ISBN (Electronic)	9781728152332
DOIs	https://doi.org/10.1109/ICLO48556.2020.9285858
State	Published - 2 Nov 2020
Externally published	Yes
Event	2020 International Conference Laser Optics, ICLO 2020 - St. Petersburg, Russian Federation Duration: 2 Nov 2020 → 6 Nov 2020

Publication series

Name	Proceedings - International Conference Laser Optics 2020, ICLO 2020

Conference

Conference	2020 International Conference Laser Optics, ICLO 2020
Country/Territory	Russian Federation
City	St. Petersburg
Period	2/11/20 → 6/11/20

UN SDGs

This output contributes to the following UN Sustainable Development Goals (SDGs)

SDG 3 Good Health and Well-being

Keywords

Cellular hitchhiking
cancer therapy
magnetic gold hybrid nanoparticles
targeted drug delivery

All Science Journal Classification (ASJC) codes

Electronic, Optical and Magnetic Materials
Atomic and Molecular Physics, and Optics

Access to Document

10.1109/ICLO48556.2020.9285858

Cite this

Yakovtseva, M. N., Betzer, O., Lunin, A. V., Mochalova, E. N., Beiderman, M., Motiei, M., Zvereva, S. D., Proushinskaya, O. B., Sadan, T., Popovtzer, R., & Nikitin, M. P. (2020). Magnetic and Gold Nanoparticles Optimized for Cancer Treatment via Cell Hitchhiking. In Proceedings - International Conference Laser Optics 2020, ICLO 2020 Article 9285858 (Proceedings - International Conference Laser Optics 2020, ICLO 2020). Institute of Electrical and Electronics Engineers Inc.. https://doi.org/10.1109/ICLO48556.2020.9285858

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title = "Magnetic and Gold Nanoparticles Optimized for Cancer Treatment via Cell Hitchhiking",

abstract = "To date, targeting cancer cells by nanoparticles has been limited due to physical and biological obstructions, including the mononuclear phagocyte system. A novel approach for prolongation of nanoparticle circulation is cellular 'hitchhiking', or use of cells as vehicles to increase co-delivery of cancer therapeutics and particles to affected tissue. In this work, we studied the main characteristics of nanoagents based on magnetic and gold particles, to ensure optimal physicochemical characteristics. The developed agents hold promise to overcome the challenges that still hinder effective drug delivery for treatment of such complex diseases as cancer.",

keywords = "Cellular hitchhiking, cancer therapy, magnetic gold hybrid nanoparticles, targeted drug delivery",

author = "Yakovtseva, \{M. N.\} and O. Betzer and Lunin, \{A. V.\} and Mochalova, \{E. N.\} and M. Beiderman and M. Motiei and Zvereva, \{S. D.\} and Proushinskaya, \{O. B.\} and T. Sadan and R. Popovtzer and Nikitin, \{M. P.\}",

note = "Publisher Copyright: {\textcopyright} 2020 IEEE.; 2020 International Conference Laser Optics, ICLO 2020 ; Conference date: 02-11-2020 Through 06-11-2020",

year = "2020",

month = nov,

day = "2",

doi = "10.1109/ICLO48556.2020.9285858",

language = "الإنجليزيّة",

series = "Proceedings - International Conference Laser Optics 2020, ICLO 2020",

publisher = "Institute of Electrical and Electronics Engineers Inc.",

booktitle = "Proceedings - International Conference Laser Optics 2020, ICLO 2020",

address = "الولايات المتّحدة",

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Yakovtseva, MN, Betzer, O, Lunin, AV, Mochalova, EN, Beiderman, M, Motiei, M, Zvereva, SD, Proushinskaya, OB, Sadan, T, Popovtzer, R & Nikitin, MP 2020, Magnetic and Gold Nanoparticles Optimized for Cancer Treatment via Cell Hitchhiking. in Proceedings - International Conference Laser Optics 2020, ICLO 2020., 9285858, Proceedings - International Conference Laser Optics 2020, ICLO 2020, Institute of Electrical and Electronics Engineers Inc., 2020 International Conference Laser Optics, ICLO 2020, St. Petersburg, Russian Federation, 2/11/20. https://doi.org/10.1109/ICLO48556.2020.9285858

Magnetic and Gold Nanoparticles Optimized for Cancer Treatment via Cell Hitchhiking. / Yakovtseva, M. N.; Betzer, O.; Lunin, A. V. et al.
Proceedings - International Conference Laser Optics 2020, ICLO 2020. Institute of Electrical and Electronics Engineers Inc., 2020. 9285858 (Proceedings - International Conference Laser Optics 2020, ICLO 2020).

Research output: Chapter in Book/Report/Conference proceeding › Conference contribution › peer-review

TY - GEN

T1 - Magnetic and Gold Nanoparticles Optimized for Cancer Treatment via Cell Hitchhiking

AU - Yakovtseva, M. N.

AU - Betzer, O.

AU - Lunin, A. V.

AU - Mochalova, E. N.

AU - Beiderman, M.

AU - Motiei, M.

AU - Zvereva, S. D.

AU - Proushinskaya, O. B.

AU - Sadan, T.

AU - Popovtzer, R.

AU - Nikitin, M. P.

PY - 2020/11/2

Y1 - 2020/11/2

N2 - To date, targeting cancer cells by nanoparticles has been limited due to physical and biological obstructions, including the mononuclear phagocyte system. A novel approach for prolongation of nanoparticle circulation is cellular 'hitchhiking', or use of cells as vehicles to increase co-delivery of cancer therapeutics and particles to affected tissue. In this work, we studied the main characteristics of nanoagents based on magnetic and gold particles, to ensure optimal physicochemical characteristics. The developed agents hold promise to overcome the challenges that still hinder effective drug delivery for treatment of such complex diseases as cancer.

AB - To date, targeting cancer cells by nanoparticles has been limited due to physical and biological obstructions, including the mononuclear phagocyte system. A novel approach for prolongation of nanoparticle circulation is cellular 'hitchhiking', or use of cells as vehicles to increase co-delivery of cancer therapeutics and particles to affected tissue. In this work, we studied the main characteristics of nanoagents based on magnetic and gold particles, to ensure optimal physicochemical characteristics. The developed agents hold promise to overcome the challenges that still hinder effective drug delivery for treatment of such complex diseases as cancer.

KW - Cellular hitchhiking

KW - cancer therapy

KW - magnetic gold hybrid nanoparticles

KW - targeted drug delivery

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DO - 10.1109/ICLO48556.2020.9285858

M3 - منشور من مؤتمر

T3 - Proceedings - International Conference Laser Optics 2020, ICLO 2020

BT - Proceedings - International Conference Laser Optics 2020, ICLO 2020

PB - Institute of Electrical and Electronics Engineers Inc.

T2 - 2020 International Conference Laser Optics, ICLO 2020

Y2 - 2 November 2020 through 6 November 2020

ER -

Yakovtseva MN, Betzer O, Lunin AV, Mochalova EN, Beiderman M, Motiei M et al. Magnetic and Gold Nanoparticles Optimized for Cancer Treatment via Cell Hitchhiking. In Proceedings - International Conference Laser Optics 2020, ICLO 2020. Institute of Electrical and Electronics Engineers Inc. 2020. 9285858. (Proceedings - International Conference Laser Optics 2020, ICLO 2020). doi: 10.1109/ICLO48556.2020.9285858

Magnetic and Gold Nanoparticles Optimized for Cancer Treatment via Cell Hitchhiking

Abstract

Publication series

Conference

UN SDGs

Keywords

All Science Journal Classification (ASJC) codes

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