Magnetic and Gold Nanoparticles Optimized for Cancer Treatment via Cell Hitchhiking

M. N. Yakovtseva, O. Betzer, A. V. Lunin, E. N. Mochalova, M. Beiderman, M. Motiei, S. D. Zvereva, O. B. Proushinskaya, T. Sadan, R. Popovtzer, M. P. Nikitin

Research output: Chapter in Book/Report/Conference proceedingConference contributionpeer-review

Abstract

To date, targeting cancer cells by nanoparticles has been limited due to physical and biological obstructions, including the mononuclear phagocyte system. A novel approach for prolongation of nanoparticle circulation is cellular 'hitchhiking', or use of cells as vehicles to increase co-delivery of cancer therapeutics and particles to affected tissue. In this work, we studied the main characteristics of nanoagents based on magnetic and gold particles, to ensure optimal physicochemical characteristics. The developed agents hold promise to overcome the challenges that still hinder effective drug delivery for treatment of such complex diseases as cancer.

Original languageEnglish
Title of host publicationProceedings - International Conference Laser Optics 2020, ICLO 2020
PublisherInstitute of Electrical and Electronics Engineers Inc.
ISBN (Electronic)9781728152332
DOIs
StatePublished - 2 Nov 2020
Externally publishedYes
Event2020 International Conference Laser Optics, ICLO 2020 - St. Petersburg, Russian Federation
Duration: 2 Nov 20206 Nov 2020

Publication series

NameProceedings - International Conference Laser Optics 2020, ICLO 2020

Conference

Conference2020 International Conference Laser Optics, ICLO 2020
Country/TerritoryRussian Federation
CitySt. Petersburg
Period2/11/206/11/20

Keywords

  • Cellular hitchhiking
  • cancer therapy
  • magnetic gold hybrid nanoparticles
  • targeted drug delivery

All Science Journal Classification (ASJC) codes

  • Electronic, Optical and Magnetic Materials
  • Atomic and Molecular Physics, and Optics

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