Macrophages and regeneration: Lessons from the heart

Jonathan Leor; Dahlia Palevski; Uri Amit; Tal Konfino

doi:https://doi.org/10.1016/j.semcdb.2016.04.012

Macrophages and regeneration: Lessons from the heart

Jonathan Leor, Dahlia Palevski, Uri Amit, Tal Konfino

Medicine Dean & Assoc. Deans

Tel Aviv University

Research output: Contribution to journal › Review article › peer-review

Abstract

One of the most ambitious goals in modern cardiology is to regenerate the injured myocardium. The human myocardium has poor regenerative power. Thus, significant myocardial injury results in irreversible damage, scar formation, remodeling, and dysfunction. The search for therapies that will improve myocardial regeneration needs a better understanding of the mechanisms of repair and regeneration. While the role of macrophages in inflammation, scar formation, and fibrosis are well defined, their role in myocardial regeneration is less clear. Recent reports have suggested that cardiac macrophages regulate myocardial regeneration in neonatal mice. The present review aims to describe the latest discoveries about the possible role of macrophages in myocardial regeneration. We discuss the promises and difficulties to translate the latest findings into new therapies.

Original language	English
Pages (from-to)	26-33
Number of pages	8
Journal	Seminars in Cell and Developmental Biology
Volume	58
DOIs	https://doi.org/10.1016/j.semcdb.2016.04.012
State	Published - 1 Oct 2016

Keywords

Heart
Inflammation
Macrophage
Monocyte
Myocardial infarction
Regeneration

All Science Journal Classification (ASJC) codes

Developmental Biology
Cell Biology

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https://doi.org/10.1016/j.semcdb.2016.04.012

Cite this

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title = "Macrophages and regeneration: Lessons from the heart",

abstract = "One of the most ambitious goals in modern cardiology is to regenerate the injured myocardium. The human myocardium has poor regenerative power. Thus, significant myocardial injury results in irreversible damage, scar formation, remodeling, and dysfunction. The search for therapies that will improve myocardial regeneration needs a better understanding of the mechanisms of repair and regeneration. While the role of macrophages in inflammation, scar formation, and fibrosis are well defined, their role in myocardial regeneration is less clear. Recent reports have suggested that cardiac macrophages regulate myocardial regeneration in neonatal mice. The present review aims to describe the latest discoveries about the possible role of macrophages in myocardial regeneration. We discuss the promises and difficulties to translate the latest findings into new therapies.",

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AU - Palevski, Dahlia

AU - Amit, Uri

AU - Konfino, Tal

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N2 - One of the most ambitious goals in modern cardiology is to regenerate the injured myocardium. The human myocardium has poor regenerative power. Thus, significant myocardial injury results in irreversible damage, scar formation, remodeling, and dysfunction. The search for therapies that will improve myocardial regeneration needs a better understanding of the mechanisms of repair and regeneration. While the role of macrophages in inflammation, scar formation, and fibrosis are well defined, their role in myocardial regeneration is less clear. Recent reports have suggested that cardiac macrophages regulate myocardial regeneration in neonatal mice. The present review aims to describe the latest discoveries about the possible role of macrophages in myocardial regeneration. We discuss the promises and difficulties to translate the latest findings into new therapies.

AB - One of the most ambitious goals in modern cardiology is to regenerate the injured myocardium. The human myocardium has poor regenerative power. Thus, significant myocardial injury results in irreversible damage, scar formation, remodeling, and dysfunction. The search for therapies that will improve myocardial regeneration needs a better understanding of the mechanisms of repair and regeneration. While the role of macrophages in inflammation, scar formation, and fibrosis are well defined, their role in myocardial regeneration is less clear. Recent reports have suggested that cardiac macrophages regulate myocardial regeneration in neonatal mice. The present review aims to describe the latest discoveries about the possible role of macrophages in myocardial regeneration. We discuss the promises and difficulties to translate the latest findings into new therapies.

KW - Heart

KW - Inflammation

KW - Macrophage

KW - Monocyte

KW - Myocardial infarction

KW - Regeneration

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M3 - مقالة مرجعية

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JO - Seminars in Cell and Developmental Biology

JF - Seminars in Cell and Developmental Biology

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Macrophages and regeneration: Lessons from the heart

Abstract

Keywords

All Science Journal Classification (ASJC) codes

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