LPS-mediated septic shock is augmented in ceramide synthase 2 null mice due to elevated activity of TNFα-converting enzyme

Muhammad Ali; Ashish Saroha; Yael Pewzner-Jung; Anthony H. Futerman

doi:10.1016/j.febslet.2015.06.045

LPS-mediated septic shock is augmented in ceramide synthase 2 null mice due to elevated activity of TNFα-converting enzyme

Muhammad Ali, Ashish Saroha, Yael Pewzner-Jung, Anthony H. Futerman

Department of Biomolecular Sciences

Weizmann Institute of Science

Research output: Contribution to journal › Article › peer-review

Abstract

Tumor necrosis factor alpha (TNF alpha) is an inflammatory cytokine that plays an intimate role in septic shock. Injection of high levels of lipopolysaccharide induces septic shock and death in mice within 30 h, whereas ceramide synthase 2 (CerS2) null mice, defective in the synthesis of very-long acyl chain ceramides, die within similar to 10 h. The augmented rate of death of CerS2 null mice is due to elevated levels of TNF alpha secretion as a result of enhanced activity of TNF alpha-converting enzyme (TACE). We discuss the relationship between the sphingolipid acyl chain length and TACE activity and the relevance of this data to septic shock.

Original language	English
Pages (from-to)	2213-2217
Number of pages	5
Journal	FEBS Letters
Volume	589
Issue number	17
Early online date	13 Jul 2015
DOIs	https://doi.org/10.1016/j.febslet.2015.06.045
State	Published - 4 Aug 2015

All Science Journal Classification (ASJC) codes

Genetics
Molecular Biology
Biophysics
Structural Biology
Biochemistry
Cell Biology

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10.1016/j.febslet.2015.06.045

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title = "LPS-mediated septic shock is augmented in ceramide synthase 2 null mice due to elevated activity of TNFα-converting enzyme",

abstract = "Tumor necrosis factor alpha (TNF alpha) is an inflammatory cytokine that plays an intimate role in septic shock. Injection of high levels of lipopolysaccharide induces septic shock and death in mice within 30 h, whereas ceramide synthase 2 (CerS2) null mice, defective in the synthesis of very-long acyl chain ceramides, die within similar to 10 h. The augmented rate of death of CerS2 null mice is due to elevated levels of TNF alpha secretion as a result of enhanced activity of TNF alpha-converting enzyme (TACE). We discuss the relationship between the sphingolipid acyl chain length and TACE activity and the relevance of this data to septic shock.",

author = "Muhammad Ali and Ashish Saroha and Yael Pewzner-Jung and Futerman, {Anthony H.}",

note = "European Union Seventh Framework Programme [FP7] (AtheroFlux) [HEALTH-F2-2013-602222]; Israel Science Foundation [0888/11] The research leading to these results received funding from the European Union Seventh Framework Programme [FP7-2007-2013] under grant agreement 'HEALTH-F2-2013-602222' (AtheroFlux), and from the Israel Science Foundation (Grant 0888/11). A.H. Futerman is the Joseph Meyerhoff Professor of Biochemistry at the Weizmann Institute of Science.",

year = "2015",

month = aug,

day = "4",

doi = "10.1016/j.febslet.2015.06.045",

language = "الإنجليزيّة",

volume = "589",

pages = "2213--2217",

journal = "FEBS Letters",

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publisher = "John Wiley and Sons Inc.",

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T1 - LPS-mediated septic shock is augmented in ceramide synthase 2 null mice due to elevated activity of TNFα-converting enzyme

AU - Ali, Muhammad

AU - Saroha, Ashish

AU - Pewzner-Jung, Yael

AU - Futerman, Anthony H.

N1 - European Union Seventh Framework Programme [FP7] (AtheroFlux) [HEALTH-F2-2013-602222]; Israel Science Foundation [0888/11] The research leading to these results received funding from the European Union Seventh Framework Programme [FP7-2007-2013] under grant agreement 'HEALTH-F2-2013-602222' (AtheroFlux), and from the Israel Science Foundation (Grant 0888/11). A.H. Futerman is the Joseph Meyerhoff Professor of Biochemistry at the Weizmann Institute of Science.

PY - 2015/8/4

Y1 - 2015/8/4

N2 - Tumor necrosis factor alpha (TNF alpha) is an inflammatory cytokine that plays an intimate role in septic shock. Injection of high levels of lipopolysaccharide induces septic shock and death in mice within 30 h, whereas ceramide synthase 2 (CerS2) null mice, defective in the synthesis of very-long acyl chain ceramides, die within similar to 10 h. The augmented rate of death of CerS2 null mice is due to elevated levels of TNF alpha secretion as a result of enhanced activity of TNF alpha-converting enzyme (TACE). We discuss the relationship between the sphingolipid acyl chain length and TACE activity and the relevance of this data to septic shock.

AB - Tumor necrosis factor alpha (TNF alpha) is an inflammatory cytokine that plays an intimate role in septic shock. Injection of high levels of lipopolysaccharide induces septic shock and death in mice within 30 h, whereas ceramide synthase 2 (CerS2) null mice, defective in the synthesis of very-long acyl chain ceramides, die within similar to 10 h. The augmented rate of death of CerS2 null mice is due to elevated levels of TNF alpha secretion as a result of enhanced activity of TNF alpha-converting enzyme (TACE). We discuss the relationship between the sphingolipid acyl chain length and TACE activity and the relevance of this data to septic shock.

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U2 - 10.1016/j.febslet.2015.06.045

DO - 10.1016/j.febslet.2015.06.045

M3 - مقالة

SN - 0014-5793

VL - 589

SP - 2213

EP - 2217

JO - FEBS Letters

JF - FEBS Letters

IS - 17

ER -

LPS-mediated septic shock is augmented in ceramide synthase 2 null mice due to elevated activity of TNFα-converting enzyme

Abstract

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