Low insulin-like growth factor-1 level predicts survival in humans with exceptional longevity

Sofiya Milman, Gil Atzmon, Derek M. Huffman, Junxiang Wan, Jill P. Crandall, Pinchas Cohen, Nir Barzilai

Research output: Contribution to journalArticlepeer-review


Attenuated growth hormone and insulin-like growth factor-1 (GH/IGF-1) signaling is associated with extended lifespan in several animal models. However, the effect of diminished GH/IGF-1 activity on survival in humans has not been confirmed. We tested the hypothesis that IGF-1 levels in nonagenarians (n = 184), measured at study enrollment, predict the duration of their incremental survival. In the Kaplan-Meier analysis, females with IGF-1 levels below the median (≤ 96 ng mL-1) had significantly longer survival compared with females with levels above the median, P < 0.01. However, this survival advantage was not observed in males (P = 0.83). On the other hand, in both males and females with a history of cancer, lower IGF-1 levels predicted longer survival (P < 0.01). IGF-1 level remained a significant predictor of survival duration in linear regression models after multivariable adjustment in females (P = 0.01) and individuals with a history of cancer (P < 0.01). We show for the first time that low IGF-1 levels predict life expectancy in exceptionally long-lived individuals.

Original languageAmerican English
Pages (from-to)769-771
Number of pages3
JournalAging Cell
Issue number4
StatePublished - Aug 2014
Externally publishedYes


  • Cancer
  • Human
  • IGF-1
  • Insulin-like growth factor 1
  • Longevity
  • Mortality

All Science Journal Classification (ASJC) codes

  • Ageing
  • Cell Biology


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