TY - JOUR
T1 - Lost after translation
T2 - Post-translational modifications by bacterial type III effectors
AU - Salomon, Dor
AU - Orth, Kim
N1 - Funding Information: We thank the Orth lab for suggestions and editing. K.O. and D.S. are supported by National Institutes of Health-AID Grant R01-AI056404 and Grant I-1561 from the Welch Research Foundation . K.O. is a Burroughs Welcome Investigator in Pathogenesis of Infectious Disease and a W.W. Caruth, Jr. Biomedical Scholar.
PY - 2013/4
Y1 - 2013/4
N2 - Many Gram-negative bacterial pathogens use the type III secretion system to deliver effector proteins into host cells. These effectors use various mechanisms to exploit host processes to the advantage of the pathogen. A large group of effectors use post-translational modifications, either reversible or irreversible, to manipulate host proteins, and while most of these mechanisms mimic eukaryotic activities, others appear to be unique biochemical functions. Deciphering such mechanisms and identifying the host targets of these effectors sheds light on eukaryotic signaling pathways and immune responses.
AB - Many Gram-negative bacterial pathogens use the type III secretion system to deliver effector proteins into host cells. These effectors use various mechanisms to exploit host processes to the advantage of the pathogen. A large group of effectors use post-translational modifications, either reversible or irreversible, to manipulate host proteins, and while most of these mechanisms mimic eukaryotic activities, others appear to be unique biochemical functions. Deciphering such mechanisms and identifying the host targets of these effectors sheds light on eukaryotic signaling pathways and immune responses.
UR - http://www.scopus.com/inward/record.url?scp=84877065790&partnerID=8YFLogxK
U2 - https://doi.org/10.1016/j.mib.2013.01.013
DO - https://doi.org/10.1016/j.mib.2013.01.013
M3 - مقالة مرجعية
SN - 1369-5274
VL - 16
SP - 213
EP - 220
JO - Current Opinion in Microbiology
JF - Current Opinion in Microbiology
IS - 2
ER -