Loss of balance between striatal feedforward inhibition and corticostriatal excitation leads to tremor

Yael Oran, Izhar Bar-Gad

Research output: Contribution to journalArticlepeer-review


Fast-spiking interneurons (FSIs) exert powerful inhibitory control over the striatum and are hypothesized to balance the massive excitatory cortical and thalamic input to this structure. We recorded neuronal activity in the dorsolateral striatum and globus pallidus (GP) concurrently with the detailed movement kinematics of freely behaving female rats before and after selective inhibition of FSI activity using IEM-1460 microinjections. The inhibition led to the appearance of episodic rest tremor in the body part that depended on the somatotopic location of the injection within the striatum. The tremor was accompanied by coherent oscillations in the local field potential (LFP). Individual neuron activity patterns became oscillatory and coherent in the tremor frequency. Striatal neurons, but not GP neurons, displayed additional temporal, nonoscillatory correlations. The subsequent reduction in the corticostriatal input following muscimol injection to the corresponding somatotopic location in the primary motor cortex led to disruption of the tremor and a reduction of the LFP oscillations and individual neuron’s phase-locked activity. The breakdown of the normal balance of excitation and inhibition in the striatum has been shown previously to be related to different motor abnormalities. Our results further indicate that the balance between excitatory corticostriatal input and feedforward FSI inhibition is sufficient to break down the striatal decorrelation process and generate oscillations resulting in rest tremor typical of multiple basal ganglia disorders.

Original languageEnglish
Pages (from-to)1699-1710
Number of pages12
JournalJournal of Neuroscience
Issue number7
StatePublished - 14 Feb 2018


  • Extracellular recording
  • Fast-spiking interneurons
  • Oscillations
  • Striatum
  • Tremor

All Science Journal Classification (ASJC) codes

  • General Neuroscience


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