Abstract
Thiazolidinedione-8 (TZD-8) is an anti-quorum-sensing molecule that has the potential to effectively prevent catheter-associated urinary tract infections, a major healthcare challenge. Sustained-release drug-delivery systems can enhance drugs' therapeutic potential, by maintaining their therapeutic level and reducing their side effects. Varnishes for sustained release of TZD-8 based on ethylcellulose or ammonio methacrylate copolymer type A (Eudragit® RL) were developed. The main factors affecting release rate were found to be film thickness and presence of a hydrophilic or swellable polymer in the matrix. The release mechanism of ethylcellulose-based systems matched the Higuchi model. Selected varnishes were retained on catheters for at least 8 days. Sustained-release delivery systems of TZD-8 were active against Candida albicans biofilms. The present study demonstrates promising results en route to developing applications for the prevention of catheter-associated infections.
Original language | English |
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Pages (from-to) | 164-170 |
Number of pages | 7 |
Journal | International Journal of Pharmaceutics |
Volume | 485 |
Issue number | 1-2 |
DOIs | |
State | Published - 15 May 2015 |
Keywords
- Catheter-associated infections
- Modeling
- Quorum sensing
- Sustained release
- Thiazolidinedione-8
- Varnish
All Science Journal Classification (ASJC) codes
- Pharmaceutical Science