Lipid droplets regulate autophagosome biogenesis

Tomer Shpilka; Zvulun Elazar; Tomer Shpilkay

doi:10.1080/15548627.2015.1093719

Lipid droplets regulate autophagosome biogenesis

Tomer Shpilka, Zvulun Elazar, Tomer Shpilkay

Department of Biomolecular Sciences

Weizmann Institute of Science

Research output: Contribution to journal › Article › peer-review

Abstract

The source of the autophagic membrane and the regulation of autophagosome biogenesis are still elusive open issues in the field of autophagy. In our recent study of the role of lipid droplets (LDs) and their constituents in autophagy, we provided evidence that both the biogenesis of LDs and its lipolysis by specific lipases are important for autophagosome biogenesis. Our study sheds new light on the source of the autophagic membrane and suggests that a flow of membranes from the endoplasmic reticulum (ER) to LDs, and from LDs to the ER, is essential for autophagosome biogenesis.

Original language	English
Pages (from-to)	2130-2131
Number of pages	2
Journal	Autophagy
Volume	11
Issue number	11
DOIs	https://doi.org/10.1080/15548627.2015.1093719
State	Published - 1 Jan 2015

Keywords

Atg8
Autophagosome biogenesis
Autophagy
Ayr1
FAS
Fatty acids
Ice2
Ldb16
Ldh1
Lipid droplets
Steryl ester
Triacylglycerols
Yeh1

All Science Journal Classification (ASJC) codes

Molecular Biology
Cell Biology

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10.1080/15548627.2015.1093719

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title = "Lipid droplets regulate autophagosome biogenesis",

abstract = "The source of the autophagic membrane and the regulation of autophagosome biogenesis are still elusive open issues in the field of autophagy. In our recent study of the role of lipid droplets (LDs) and their constituents in autophagy, we provided evidence that both the biogenesis of LDs and its lipolysis by specific lipases are important for autophagosome biogenesis. Our study sheds new light on the source of the autophagic membrane and suggests that a flow of membranes from the endoplasmic reticulum (ER) to LDs, and from LDs to the ER, is essential for autophagosome biogenesis.",

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AB - The source of the autophagic membrane and the regulation of autophagosome biogenesis are still elusive open issues in the field of autophagy. In our recent study of the role of lipid droplets (LDs) and their constituents in autophagy, we provided evidence that both the biogenesis of LDs and its lipolysis by specific lipases are important for autophagosome biogenesis. Our study sheds new light on the source of the autophagic membrane and suggests that a flow of membranes from the endoplasmic reticulum (ER) to LDs, and from LDs to the ER, is essential for autophagosome biogenesis.

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KW - Autophagy

KW - Ayr1

KW - FAS

KW - Fatty acids

KW - Ice2

KW - Ldb16

KW - Ldh1

KW - Lipid droplets

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DO - 10.1080/15548627.2015.1093719

M3 - مقالة

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JO - Autophagy

JF - Autophagy

IS - 11

ER -

Lipid droplets regulate autophagosome biogenesis

Abstract

Keywords

All Science Journal Classification (ASJC) codes

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