Leveraging valine-restriction-induced DNA damage for targeted cancer therapy

Alma Sophia Barisaac; Enas R. Abu-Zhayia; Nabieh Ayoub

doi:10.1016/j.molcel.2025.01.005

Leveraging valine-restriction-induced DNA damage for targeted cancer therapy

Alma Sophia Barisaac
, Enas R. Abu-Zhayia
, Nabieh Ayoub

Biology

Technion - Israel Institute of Technology

Research output: Contribution to journal › Comment/debate

Abstract

Metabolite microenvironment shapes cancer treatment strategies. In a recent paper in Nature, Jin et al.¹ demonstrate that valine deprivation triggers HDAC6 entry into the nucleus, leading to accumulation of DNA damage that could be harnessed for targeted cancer therapy.

Original language	English
Pages (from-to)	468-470
Number of pages	3
Journal	Molecular Cell
Volume	85
Issue number	3
DOIs	https://doi.org/10.1016/j.molcel.2025.01.005
State	Published - 6 Feb 2025

UN SDGs

This output contributes to the following UN Sustainable Development Goals (SDGs)

SDG 3 Good Health and Well-being

ASJC Scopus subject areas

Molecular Biology
Cell Biology

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10.1016/j.molcel.2025.01.005

Cite this

@article{c6dc9cf7d2d84b048fcf3288afe9bf91,

title = "Leveraging valine-restriction-induced DNA damage for targeted cancer therapy",

abstract = "Metabolite microenvironment shapes cancer treatment strategies. In a recent paper in Nature, Jin et al.1 demonstrate that valine deprivation triggers HDAC6 entry into the nucleus, leading to accumulation of DNA damage that could be harnessed for targeted cancer therapy.",

author = "Barisaac, \{Alma Sophia\} and Abu-Zhayia, \{Enas R.\} and Nabieh Ayoub",

note = "Publisher Copyright: {\textcopyright} 2025 Elsevier Inc.",

year = "2025",

month = feb,

day = "6",

doi = "10.1016/j.molcel.2025.01.005",

language = "الإنجليزيّة",

volume = "85",

pages = "468--470",

journal = "Molecular Cell",

issn = "1097-2765",

publisher = "Cell Press",

number = "3",

}

TY - JOUR

T1 - Leveraging valine-restriction-induced DNA damage for targeted cancer therapy

AU - Barisaac, Alma Sophia

AU - Abu-Zhayia, Enas R.

AU - Ayoub, Nabieh

PY - 2025/2/6

Y1 - 2025/2/6

N2 - Metabolite microenvironment shapes cancer treatment strategies. In a recent paper in Nature, Jin et al.1 demonstrate that valine deprivation triggers HDAC6 entry into the nucleus, leading to accumulation of DNA damage that could be harnessed for targeted cancer therapy.

AB - Metabolite microenvironment shapes cancer treatment strategies. In a recent paper in Nature, Jin et al.1 demonstrate that valine deprivation triggers HDAC6 entry into the nucleus, leading to accumulation of DNA damage that could be harnessed for targeted cancer therapy.

UR - https://www.scopus.com/pages/publications/85216550403

U2 - 10.1016/j.molcel.2025.01.005

DO - 10.1016/j.molcel.2025.01.005

M3 - تعليقَ / نقاش

SN - 1097-2765

VL - 85

SP - 468

EP - 470

JO - Molecular Cell

JF - Molecular Cell

IS - 3

ER -

Leveraging valine-restriction-induced DNA damage for targeted cancer therapy

Abstract

UN SDGs

ASJC Scopus subject areas

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