Leveraging valine-restriction-induced DNA damage for targeted cancer therapy

Alma Sophia Barisaac; Enas R. Abu-Zhayia; Nabieh Ayoub

doi:https://doi.org/10.1016/j.molcel.2025.01.005

Leveraging valine-restriction-induced DNA damage for targeted cancer therapy

Alma Sophia Barisaac, Enas R. Abu-Zhayia, Nabieh Ayoub

Biology

Technion - Israel Institute of Technology

Research output: Contribution to journal › Comment/debate

Abstract

Metabolite microenvironment shapes cancer treatment strategies. In a recent paper in Nature, Jin et al.¹ demonstrate that valine deprivation triggers HDAC6 entry into the nucleus, leading to accumulation of DNA damage that could be harnessed for targeted cancer therapy.

Original language	English
Pages (from-to)	468-470
Number of pages	3
Journal	Molecular Cell
Volume	85
Issue number	3
DOIs	https://doi.org/10.1016/j.molcel.2025.01.005
State	Published - 6 Feb 2025

All Science Journal Classification (ASJC) codes

Molecular Biology
Cell Biology

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https://doi.org/10.1016/j.molcel.2025.01.005

Cite this

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title = "Leveraging valine-restriction-induced DNA damage for targeted cancer therapy",

abstract = "Metabolite microenvironment shapes cancer treatment strategies. In a recent paper in Nature, Jin et al.1 demonstrate that valine deprivation triggers HDAC6 entry into the nucleus, leading to accumulation of DNA damage that could be harnessed for targeted cancer therapy.",

author = "Barisaac, {Alma Sophia} and Abu-Zhayia, {Enas R.} and Nabieh Ayoub",

note = "Publisher Copyright: {\textcopyright} 2025 Elsevier Inc.",

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doi = "https://doi.org/10.1016/j.molcel.2025.01.005",

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T1 - Leveraging valine-restriction-induced DNA damage for targeted cancer therapy

AU - Barisaac, Alma Sophia

AU - Abu-Zhayia, Enas R.

AU - Ayoub, Nabieh

PY - 2025/2/6

Y1 - 2025/2/6

N2 - Metabolite microenvironment shapes cancer treatment strategies. In a recent paper in Nature, Jin et al.1 demonstrate that valine deprivation triggers HDAC6 entry into the nucleus, leading to accumulation of DNA damage that could be harnessed for targeted cancer therapy.

AB - Metabolite microenvironment shapes cancer treatment strategies. In a recent paper in Nature, Jin et al.1 demonstrate that valine deprivation triggers HDAC6 entry into the nucleus, leading to accumulation of DNA damage that could be harnessed for targeted cancer therapy.

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U2 - https://doi.org/10.1016/j.molcel.2025.01.005

DO - https://doi.org/10.1016/j.molcel.2025.01.005

M3 - تعليقَ / نقاش

SN - 1097-2765

VL - 85

SP - 468

EP - 470

JO - Molecular Cell

JF - Molecular Cell

IS - 3

ER -

Leveraging valine-restriction-induced DNA damage for targeted cancer therapy

Abstract

All Science Journal Classification (ASJC) codes

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