TY - JOUR
T1 - Leveraging technology to probe mechanisms of psychopathology
T2 - A proof of concept study of inhibitory control
AU - Cardinale, Elise M.
AU - Meigs, Jennifer M.
AU - Haller, Simone P.
AU - Fling, Kenny
AU - Pandya, Urmi
AU - Siegal, Olivia
AU - Poe, Anjali
AU - Shaughnessy, Shannon
AU - Zapp, Christian
AU - Bezek, Jessica L.
AU - Lee, Kyunghun
AU - Khosravi, Parmis
AU - German, Ramaris
AU - Jangraw, David C.
AU - Henry, Lauren M.
AU - Byrne, Meghan E.
AU - Kircanski, Katharina
AU - Leibenluft, Ellen
AU - Naim, Reut
AU - Pine, Daniel S.
AU - Brotman, Melissa A.
N1 - Publisher Copyright: This is an open access article, free of all copyright, and may be freely reproduced, distributed, transmitted, modified, built upon, or otherwise used by anyone for any lawful purpose. The work is made available under the Creative Commons CC0 public domain dedication.
PY - 2025/6
Y1 - 2025/6
N2 - Objective Quantifying relevant behavioral mechanisms has relied on rigorous, time-consuming tools restricted to laboratory settings and inaccessible to the clinical community. Advances in technology provide an opportunity to develop more accessible platforms. Here, we developed CALM-IT, a novel mobile-application to experimentally assess inhibitory control in vivo Method In a transdiagnostic sample of 200 youth aged 8–20, we (i) apply knowledge from canonical inhibitory control tasks in the methodological design of the mobile application, (ii) establish feasibility and engagement with CALM-IT, (iii) assess test-retest reliability of CALM-IT, (iv) investigate the convergent validity of CALM-IT with behavioral and neural responses to laboratory-based tasks, and (v) probe clinical relevance via associations with clinical symptoms. Results First, we provide evidence that our novel inhibitory control mobile application, CALM-IT, was accessible, feasible, and engaging. Second, we found performance was reliable over time. Third, we found CALM-IT performance was associated with established measures of inhibitory control and activation in the bilateral inferior frontal gyrus. Associations with brain but not behavior survived after controlling for age. Finally, we found evidence linking impaired CALM-IT performance to increased levels of co-occurring anxiety, irritability, and attention deficit hyperactivity disorder (ADHD) symptoms. Conclusion Validation of this neuroscience-informed mobile application represents a critical first step in bridging precise, mechanism-driven research and community-based assessment of childhood psychopathology. The present work lays the groundwork for future research that could provide researchers and clinicians with a multifaceted tool to measure clinically-relevant behaviors in an engaging and accessible manner.
AB - Objective Quantifying relevant behavioral mechanisms has relied on rigorous, time-consuming tools restricted to laboratory settings and inaccessible to the clinical community. Advances in technology provide an opportunity to develop more accessible platforms. Here, we developed CALM-IT, a novel mobile-application to experimentally assess inhibitory control in vivo Method In a transdiagnostic sample of 200 youth aged 8–20, we (i) apply knowledge from canonical inhibitory control tasks in the methodological design of the mobile application, (ii) establish feasibility and engagement with CALM-IT, (iii) assess test-retest reliability of CALM-IT, (iv) investigate the convergent validity of CALM-IT with behavioral and neural responses to laboratory-based tasks, and (v) probe clinical relevance via associations with clinical symptoms. Results First, we provide evidence that our novel inhibitory control mobile application, CALM-IT, was accessible, feasible, and engaging. Second, we found performance was reliable over time. Third, we found CALM-IT performance was associated with established measures of inhibitory control and activation in the bilateral inferior frontal gyrus. Associations with brain but not behavior survived after controlling for age. Finally, we found evidence linking impaired CALM-IT performance to increased levels of co-occurring anxiety, irritability, and attention deficit hyperactivity disorder (ADHD) symptoms. Conclusion Validation of this neuroscience-informed mobile application represents a critical first step in bridging precise, mechanism-driven research and community-based assessment of childhood psychopathology. The present work lays the groundwork for future research that could provide researchers and clinicians with a multifaceted tool to measure clinically-relevant behaviors in an engaging and accessible manner.
UR - http://www.scopus.com/inward/record.url?scp=105007990607&partnerID=8YFLogxK
U2 - 10.1371/journal.pone.0319004
DO - 10.1371/journal.pone.0319004
M3 - مقالة
C2 - 40479619
SN - 1932-6203
VL - 20
JO - PLoS ONE
JF - PLoS ONE
IS - 6 June
M1 - e0319004
ER -