Leveraging nematocysts toward human care

Tamar Lotan

doi:10.1007/978-3-319-31305-4_42

Leveraging nematocysts toward human care

Tamar Lotan

Department of Marine Biology

University of Haifa

Research output: Chapter in Book/Report/Conference proceeding › Chapter › peer-review

Abstract

The stinging cells of cnidarians contain nematocysts, which are a sophisticated ultra-fast injection system that can penetrate the skin immediately. This chapter will review two nematocyst-based biotechnology applications. The first hinders nematocyst discharge and thereby prevents jellyfish envenomation. The development of the inhibitory formulation and the demonstration of its effectiveness by clinical trials will be described. The second application utilizes isolated nematocysts as micro-devices for active drug delivery. The advantages of this novel approach will be demonstrated by the results of in vitro and in vivo pharmacokinetics studies.

Original language	American English
Title of host publication	The Cnidaria, past, present and Future
Subtitle of host publication	The World of Medusa and her Sisters
Pages	683-690
Number of pages	8
ISBN (Electronic)	9783319313054
DOIs	https://doi.org/10.1007/978-3-319-31305-4_42
State	Published - 1 Jan 2016

Keywords

Active transdermal drug delivery
Jellyfish envenomation
Micro drug device
Nematocyst discharge
Sting inhibition

All Science Journal Classification (ASJC) codes

General Environmental Science
General Agricultural and Biological Sciences
General Earth and Planetary Sciences

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10.1007/978-3-319-31305-4_42

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abstract = "The stinging cells of cnidarians contain nematocysts, which are a sophisticated ultra-fast injection system that can penetrate the skin immediately. This chapter will review two nematocyst-based biotechnology applications. The first hinders nematocyst discharge and thereby prevents jellyfish envenomation. The development of the inhibitory formulation and the demonstration of its effectiveness by clinical trials will be described. The second application utilizes isolated nematocysts as micro-devices for active drug delivery. The advantages of this novel approach will be demonstrated by the results of in vitro and in vivo pharmacokinetics studies.",

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AB - The stinging cells of cnidarians contain nematocysts, which are a sophisticated ultra-fast injection system that can penetrate the skin immediately. This chapter will review two nematocyst-based biotechnology applications. The first hinders nematocyst discharge and thereby prevents jellyfish envenomation. The development of the inhibitory formulation and the demonstration of its effectiveness by clinical trials will be described. The second application utilizes isolated nematocysts as micro-devices for active drug delivery. The advantages of this novel approach will be demonstrated by the results of in vitro and in vivo pharmacokinetics studies.

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KW - Sting inhibition

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BT - The Cnidaria, past, present and Future

ER -

Leveraging nematocysts toward human care

Abstract

Keywords

All Science Journal Classification (ASJC) codes

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