Lesion-symptom mapping

Dagmar Timmann, Thomas M. Ernst, Winfried Ilg, Opher Donchin

Research output: Chapter in Book/Report/Conference proceedingChapterpeer-review


A traditional approach to studying cerebellar function is examining impairment in human subjects with cerebellar disease. High-resolution structural brain imaging coupled with tools that perform lesion-symptom mapping produced major advances in localization of function within the human cerebellum. Lesionsymptom mapping is also called lesion-behavior mapping and lesion-defi cit mapping. To localize function, patients should be included who have lesions restricted to the cerebellum. These patients are rare. Group sizes are commonly much smaller than in comparable studies with cerebral stroke. Methods will be discussed which are currently available to perform lesion-symptom mapping in patients with focal and degenerative cerebellar disease.

Original languageAmerican English
Title of host publicationEssentials of Cerebellum and Cerebellar Disorders
Subtitle of host publicationA Primer for Graduate Students
Number of pages9
ISBN (Electronic)9783319245515
StatePublished - 1 Jan 2016


  • Cerebellar function
  • Lesion-behavior
  • Lesion-defi cit
  • Lesion-symptom
  • Mapping

All Science Journal Classification (ASJC) codes

  • General Biochemistry,Genetics and Molecular Biology
  • General Neuroscience
  • General Agricultural and Biological Sciences
  • General Medicine


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