Left Ventricular Mass as a Risk Factor in the Oldest Old

Michael Bursztyn; David Leibowitz; Irit Stessman-Lande; Jeremy M. Jacobs; Eliana Ein-Mor; Jochanan Stessman

doi:10.1111/jch.12594

Left Ventricular Mass as a Risk Factor in the Oldest Old

Michael Bursztyn, David Leibowitz, Irit Stessman-Lande, Jeremy M. Jacobs, Eliana Ein-Mor, Jochanan Stessman

Research output: Contribution to journal › Article › peer-review

Abstract

In middle-aged and "young elderly" cohorts, higher left ventricular mass (LVM) is associated with worse outcomes. The authors examined LVM and 5-year mortality among community-dwelling 85-year-old patients. A representative sample (n=526, born 1920-1921) from the Jerusalem Longitudinal Cohort Study underwent echocardiography at age 85. LVM was indexed by body surface area (LVM-BSA) or height (LVM-Ht). Patients with higher LVM were less educated and sedentary and had poorer self-rated health, functional limitations, and increased comorbidity. Five-year mortality was 21.7% (n=114). Adjusted 5-year mortality rates were increased for the two upper quintiles of LVM-BSA (hazard ratio [HR], 1.8; 95% confidence interval [CI], 1.05-3.06) and LVM-Ht (HR, 2.2; 95% CI, 1.2-3.5). A step up in mortality occurred around the third quintile corresponding with LVM-BSA 110 g/m² or LVM-Ht 51 g/m^2.7. Among the oldest old, elevated LVM is significantly associated with mortality.

Original language	English
Pages (from-to)	874-879
Number of pages	6
Journal	Journal of Clinical Hypertension
Volume	17
Issue number	11
DOIs	https://doi.org/10.1111/jch.12594
State	Published - Nov 2015
Externally published	Yes

All Science Journal Classification (ASJC) codes

Cardiology and Cardiovascular Medicine
Internal Medicine
Endocrinology, Diabetes and Metabolism

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10.1111/jch.12594

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title = "Left Ventricular Mass as a Risk Factor in the Oldest Old",

abstract = "In middle-aged and {"}young elderly{"} cohorts, higher left ventricular mass (LVM) is associated with worse outcomes. The authors examined LVM and 5-year mortality among community-dwelling 85-year-old patients. A representative sample (n=526, born 1920-1921) from the Jerusalem Longitudinal Cohort Study underwent echocardiography at age 85. LVM was indexed by body surface area (LVM-BSA) or height (LVM-Ht). Patients with higher LVM were less educated and sedentary and had poorer self-rated health, functional limitations, and increased comorbidity. Five-year mortality was 21.7% (n=114). Adjusted 5-year mortality rates were increased for the two upper quintiles of LVM-BSA (hazard ratio [HR], 1.8; 95% confidence interval [CI], 1.05-3.06) and LVM-Ht (HR, 2.2; 95% CI, 1.2-3.5). A step up in mortality occurred around the third quintile corresponding with LVM-BSA 110 g/m2 or LVM-Ht 51 g/m2.7. Among the oldest old, elevated LVM is significantly associated with mortality.",

author = "Michael Bursztyn and David Leibowitz and Irit Stessman-Lande and Jacobs, {Jeremy M.} and Eliana Ein-Mor and Jochanan Stessman",

note = "Publisher Copyright: {\textcopyright} 2015 Wiley Periodicals, Inc.",

year = "2015",

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doi = "10.1111/jch.12594",

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T1 - Left Ventricular Mass as a Risk Factor in the Oldest Old

AU - Bursztyn, Michael

AU - Leibowitz, David

AU - Stessman-Lande, Irit

AU - Jacobs, Jeremy M.

AU - Ein-Mor, Eliana

AU - Stessman, Jochanan

PY - 2015/11

Y1 - 2015/11

N2 - In middle-aged and "young elderly" cohorts, higher left ventricular mass (LVM) is associated with worse outcomes. The authors examined LVM and 5-year mortality among community-dwelling 85-year-old patients. A representative sample (n=526, born 1920-1921) from the Jerusalem Longitudinal Cohort Study underwent echocardiography at age 85. LVM was indexed by body surface area (LVM-BSA) or height (LVM-Ht). Patients with higher LVM were less educated and sedentary and had poorer self-rated health, functional limitations, and increased comorbidity. Five-year mortality was 21.7% (n=114). Adjusted 5-year mortality rates were increased for the two upper quintiles of LVM-BSA (hazard ratio [HR], 1.8; 95% confidence interval [CI], 1.05-3.06) and LVM-Ht (HR, 2.2; 95% CI, 1.2-3.5). A step up in mortality occurred around the third quintile corresponding with LVM-BSA 110 g/m2 or LVM-Ht 51 g/m2.7. Among the oldest old, elevated LVM is significantly associated with mortality.

AB - In middle-aged and "young elderly" cohorts, higher left ventricular mass (LVM) is associated with worse outcomes. The authors examined LVM and 5-year mortality among community-dwelling 85-year-old patients. A representative sample (n=526, born 1920-1921) from the Jerusalem Longitudinal Cohort Study underwent echocardiography at age 85. LVM was indexed by body surface area (LVM-BSA) or height (LVM-Ht). Patients with higher LVM were less educated and sedentary and had poorer self-rated health, functional limitations, and increased comorbidity. Five-year mortality was 21.7% (n=114). Adjusted 5-year mortality rates were increased for the two upper quintiles of LVM-BSA (hazard ratio [HR], 1.8; 95% confidence interval [CI], 1.05-3.06) and LVM-Ht (HR, 2.2; 95% CI, 1.2-3.5). A step up in mortality occurred around the third quintile corresponding with LVM-BSA 110 g/m2 or LVM-Ht 51 g/m2.7. Among the oldest old, elevated LVM is significantly associated with mortality.

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U2 - 10.1111/jch.12594

DO - 10.1111/jch.12594

M3 - مقالة

C2 - 26075863

SN - 1524-6175

VL - 17

SP - 874

EP - 879

JO - Journal of Clinical Hypertension

JF - Journal of Clinical Hypertension

IS - 11

ER -

Left Ventricular Mass as a Risk Factor in the Oldest Old

Abstract

All Science Journal Classification (ASJC) codes

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