Learning-induced modulation of the GABAB-mediated inhibitory synaptic transmission: Mechanisms and functional significance

Adi Kfir, Naama Ohad-Giwnewer, Luna Jammal, Drorit Saar, David Golomb, Edi Barkai

Research output: Contribution to journalArticlepeer-review

Abstract

Complex olfactory-discrimination (OD) learning results in a series of intrinsic and excitatory synaptic modifications in piriform cortex pyramidal neurons that enhance the circuit excitability. Such overexcitation must be balanced to prevent runway activity while maintaining the efficient ability to store memories. We showed previously that OD learning is accompanied by enhancement of the GABAA-mediated inhibition. Here we show that GABAB-mediated inhibition is also enhanced after learning and study the mechanism underlying such enhancement and explore its functional role. We show that presynaptic, GABAB-mediated synaptic inhibition is enhanced after learning. In contrast, the population- average postsynaptic GABAB-mediated synaptic inhibition is unchanged, but its standard deviation is enhanced. Learning-induced reduction in paired pulse facilitation in the glutamatergic synapses interconnecting pyramidal neurons was abolished by application of the GABAB antagonist CGP55845 but not by blocking G proteingated inwardly rectifying potassium channels only, indicating enhanced suppression of excitatory synaptic release via presynaptic GABAB-receptor activation. In addition, the correlation between the strengths of the early (GABAA-mediated) and late (GABAB-mediated) synaptic inhibition was much stronger for each particular neuron after learning. Consequently, GABAB-mediated inhibition was also more efficient in controlling epileptic-like activity induced by blocking GABAA receptors. We suggest that complex OD learning is accompanied by enhancement of the GABAB-mediated inhibition that enables the cortical network to store memories, while preventing uncontrolled activity.

Original languageAmerican English
Pages (from-to)2029-2038
Number of pages10
JournalJournal of Neurophysiology
Volume111
Issue number10
DOIs
StatePublished - 1 Jan 2014

Keywords

  • Brain slices
  • Olfactory-discrimination learning
  • Piriform cortex
  • Synaptic inhibition

All Science Journal Classification (ASJC) codes

  • General Neuroscience
  • Physiology

Fingerprint

Dive into the research topics of 'Learning-induced modulation of the GABAB-mediated inhibitory synaptic transmission: Mechanisms and functional significance'. Together they form a unique fingerprint.

Cite this