Law of corresponding states for osmotic swelling of vesicles

Primo Peterlin, Vesna Arrigler, Emir Haleva, Haim Diamant

Research output: Contribution to journalArticlepeer-review

Abstract

As solute molecules permeate into a vesicle due to a concentration difference across its membrane, the vesicle swells through osmosis. The swelling can be divided into two stages: (a) an "ironing" stage, where the volume-to-area ratio of the vesicle increases without a significant change in its area; (b) a stretching stage, where the vesicle grows while remaining essentially spherical, until it ruptures. We show that the crossover between these two stages can be represented as a broadened continuous phase transition. Consequently, the swelling curves for different vesicles and different permeating solutes can be rescaled into a single, theoretically predicted, universal curve. Such a data collapse is demonstrated for giant unilamellar POPC vesicles, osmotically swollen due to the permeation of urea, glycerol, or ethylene glycol. We thereby gain a sensitive measurement of the solutes' membrane permeability coefficients, finding a concentration-independent coefficient for urea, while those of glycerol and ethylene glycol are found to increase with solute concentration. In addition, we use the width of the transition, as extracted from the data collapse, to infer the number of independent bending modes that affect the thermodynamics of the vesicle in the transition region.

Original languageEnglish
Pages (from-to)2185-2193
Number of pages9
JournalSoft Matter
Volume8
Issue number7
DOIs
StatePublished - 21 Feb 2012

All Science Journal Classification (ASJC) codes

  • General Chemistry
  • Condensed Matter Physics

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