Large-Scale Exome Sequencing Study Implicates Both Developmental and Functional Changes in the Neurobiology of Autism

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Research output: Contribution to journalArticlepeer-review

Abstract

Large-scale sequencing of patients with autism allows identification of over 100 putative ASD-associated genes, the majority of which are neuronally expressed, and investigation of distinct genetic influences on ASD compared with other neurodevelopmental disorders.

Original languageEnglish
Pages (from-to)568-584.e23
JournalCell
Volume180
Issue number3
DOIs
StatePublished - 6 Feb 2020

Keywords

  • autism spectrum disorder
  • cell type
  • cytoskeleton
  • excitatory neurons
  • excitatory-inhibitory balance
  • exome sequencing
  • genetics
  • inhibitory neurons
  • liability
  • neurodevelopment

All Science Journal Classification (ASJC) codes

  • Biochemistry, Genetics and Molecular Biology(all)

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