Large-scale cellular-resolution imaging of neural activity in freely behaving mice

D.P. Leman; I.A. Chen; K.A. Bolding; J. Tai; L. Wilmerding; H. Gritton; Yarden Cohen; W. Yen; L Nathan Perkins; William A Liberti, 3rd; K. Kilic; X. Han; A. Cruz-Martín; Timothy J. Gardner; Timothy M. Otchy; I. Davison

doi:https://doi.org/10.1101/2021.01.15.426462

Large-scale cellular-resolution imaging of neural activity in freely behaving mice

D.P. Leman, I.A. Chen, K.A. Bolding, J. Tai, L. Wilmerding, H. Gritton, Yarden Cohen, W. Yen, L Nathan Perkins, William A Liberti, 3rd, K. Kilic, X. Han, A. Cruz-Martín, Timothy J. Gardner, Timothy M. Otchy, I. Davison

Research output: Contribution to journal › Article

Abstract

Miniaturized microscopes for head-mounted fluorescence imaging are powerful tools for visualizing neural activity during naturalistic behaviors, but the restricted field of view of first-generation ‘miniscopes’ limits the size of neural populations accessible for imaging. Here we describe a novel miniaturized mesoscope offering cellular-resolution imaging over areas spanning several millimeters in freely moving mice. This system enables comprehensive visualization of activity across entire brain regions or interactions across areas.

Original language	English
Number of pages	21
Journal	bioRxiv
DOIs	https://doi.org/10.1101/2021.01.15.426462
State	Submitted - 17 Jan 2021
Externally published	Yes

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Leman, D. P., Chen, I. A., Bolding, K. A., Tai, J., Wilmerding, L., Gritton, H., Cohen, Y., Yen, W., Perkins, L. N., Liberti, 3rd, W. A., Kilic, K., Han, X., Cruz-Martín, A., Gardner, T. J., Otchy, T. M., & Davison, I. (2021). Large-scale cellular-resolution imaging of neural activity in freely behaving mice. Manuscript submitted for publication. https://doi.org/10.1101/2021.01.15.426462

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title = "Large-scale cellular-resolution imaging of neural activity in freely behaving mice",

abstract = "Miniaturized microscopes for head-mounted fluorescence imaging are powerful tools for visualizing neural activity during naturalistic behaviors, but the restricted field of view of first-generation {\textquoteleft}miniscopes{\textquoteright} limits the size of neural populations accessible for imaging. Here we describe a novel miniaturized mesoscope offering cellular-resolution imaging over areas spanning several millimeters in freely moving mice. This system enables comprehensive visualization of activity across entire brain regions or interactions across areas.",

author = "D.P. Leman and I.A. Chen and K.A. Bolding and J. Tai and L. Wilmerding and H. Gritton and Yarden Cohen and W. Yen and Perkins, {L Nathan} and {Liberti, 3rd}, {William A} and K. Kilic and X. Han and A. Cruz-Mart{\'i}n and Gardner, {Timothy J.} and Otchy, {Timothy M.} and I. Davison",

year = "2021",

month = jan,

day = "17",

doi = "https://doi.org/10.1101/2021.01.15.426462",

language = "الإنجليزيّة",

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TY - JOUR

T1 - Large-scale cellular-resolution imaging of neural activity in freely behaving mice

AU - Leman, D.P.

AU - Chen, I.A.

AU - Bolding, K.A.

AU - Tai, J.

AU - Wilmerding, L.

AU - Gritton, H.

AU - Cohen, Yarden

AU - Yen, W.

AU - Perkins, L Nathan

AU - Liberti, 3rd, William A

AU - Kilic, K.

AU - Han, X.

AU - Cruz-Martín, A.

AU - Gardner, Timothy J.

AU - Otchy, Timothy M.

AU - Davison, I.

PY - 2021/1/17

Y1 - 2021/1/17

N2 - Miniaturized microscopes for head-mounted fluorescence imaging are powerful tools for visualizing neural activity during naturalistic behaviors, but the restricted field of view of first-generation ‘miniscopes’ limits the size of neural populations accessible for imaging. Here we describe a novel miniaturized mesoscope offering cellular-resolution imaging over areas spanning several millimeters in freely moving mice. This system enables comprehensive visualization of activity across entire brain regions or interactions across areas.

AB - Miniaturized microscopes for head-mounted fluorescence imaging are powerful tools for visualizing neural activity during naturalistic behaviors, but the restricted field of view of first-generation ‘miniscopes’ limits the size of neural populations accessible for imaging. Here we describe a novel miniaturized mesoscope offering cellular-resolution imaging over areas spanning several millimeters in freely moving mice. This system enables comprehensive visualization of activity across entire brain regions or interactions across areas.

U2 - https://doi.org/10.1101/2021.01.15.426462

DO - https://doi.org/10.1101/2021.01.15.426462

M3 - مقالة

SN - 2692-8205

JO - bioRxiv

JF - bioRxiv

ER -

Large-scale cellular-resolution imaging of neural activity in freely behaving mice

Abstract

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