Large-scale cellular-resolution imaging of neural activity in freely behaving mice

D.P. Leman, I.A. Chen, K.A. Bolding, J. Tai, L. Wilmerding, H. Gritton, Yarden Cohen, W. Yen, L Nathan Perkins, William A Liberti, 3rd, K. Kilic, X. Han, A. Cruz-Martín, Timothy J. Gardner, Timothy M. Otchy, I. Davison

Research output: Contribution to journalArticle

Abstract

Miniaturized microscopes for head-mounted fluorescence imaging are powerful tools for visualizing neural activity during naturalistic behaviors, but the restricted field of view of first-generation ‘miniscopes’ limits the size of neural populations accessible for imaging. Here we describe a novel miniaturized mesoscope offering cellular-resolution imaging over areas spanning several millimeters in freely moving mice. This system enables comprehensive visualization of activity across entire brain regions or interactions across areas.
Original languageEnglish
Number of pages21
JournalbioRxiv
DOIs
StateSubmitted - 17 Jan 2021
Externally publishedYes

Fingerprint

Dive into the research topics of 'Large-scale cellular-resolution imaging of neural activity in freely behaving mice'. Together they form a unique fingerprint.

Cite this