Large-field-of-view optical-resolution optoacoustic microscopy using a stationary silicon-photonics acoustic detector

Tamar Harary, Michael Nagli, Nathan Suleymanov, Ilya Goykhman, Amir Rosenthal

Research output: Contribution to journalArticlepeer-review

Abstract

Significance: Optical-resolution optoacoustic microscopy (OR-OAM) enables label-free imaging of the microvasculature by using optical pulse excitation and acoustic detection, commonly performed by a focused optical beam and an ultrasound transducer. One of the main challenges of OR-OAM is the need to combine the excitation and detection in a coaxial configuration, often leading to a bulky setup that requires physically scanning the ultrasound transducer to achieve a large field of view. Aim: The aim of this work is to develop an OR-OAM configuration that does not require physically scanning the ultrasound transducer or the acoustic beam path. Approach: Our OR-OAM system is based on a non-coaxial configuration in which the detection is performed by a silicon-photonics acoustic detector (SPADE) with a semi-isotropic sensitivity. The system is demonstrated in both epi- and trans-illumination configurations, where in both configurations SPADE remains stationary during the imaging procedure and only the optical excitation beam is scanned. Results: The system is showcased for imaging resolution targets and for the in vivo visualization of the microvasculature in a mouse ear. Optoacoustic imaging with focal spots down to formula presented , lateral resolution of formula presented , and a field of view higher than 4 mm in both lateral dimensions were demonstrated. Conclusions: We showcase a new OR-OAM design, compatible with epi-illumination configuration. This setup enables relatively large fields of view without scanning the acoustic detector or acoustic beam path. Furthermore, it offers the potential for high-speed imaging within compact, miniature probe and could potentially facilitate the clinical translation of OR-OAM technology.

Original languageEnglish
Pages (from-to)S11511
JournalJournal of Biomedical Optics
Volume29
DOIs
StatePublished - 1 Jan 2024

Keywords

  • imaging techniques
  • micro-ring silicon-photonics acoustic detector
  • optical-resolution optoacoustic microscopy
  • photoacoustic imaging
  • silicon-photonics acoustic detector

All Science Journal Classification (ASJC) codes

  • Electronic, Optical and Magnetic Materials
  • Atomic and Molecular Physics, and Optics
  • Biomedical Engineering
  • Biomaterials

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