Lack of association between severity of ADHD symptoms and salivary oxytocin levels

Dennis Boyle; Orit Levi-Shachar; Hila Z. Gvirts; Orna Zagoory-Sharon; Ruth Feldman; Yuval Bloch; Uriel Nitzan; Hagai Maoz

doi:10.1016/j.psyneuen.2021.105293

Lack of association between severity of ADHD symptoms and salivary oxytocin levels

Dennis Boyle
, Orit Levi-Shachar
, Hila Z. Gvirts
, Orna Zagoory-Sharon
, Ruth Feldman
, Yuval Bloch
, Uriel Nitzan
, Hagai Maoz

Tel Aviv University, Ariel University

Research output: Contribution to journal › Article › peer-review

Abstract

Impairments in the reactivity of Oxytocin (OT) system were associated with interpersonal difficulties in children with ADHD. The current study aimed to explore the correlation between symptoms severity and salivary OT levels at different time-points in children with ADHD. Symptoms severity was assessed in 50 children with ADHD (28 males, mean age 9.42 ± 1.65) using the Swanson, Nolan and Pelham Questionnaire-IV (SNAP-IV) and the Strengths and Difficulties Questionnaire (SDQ). Salivary OT levels were measured at baseline, as well as 15 min after positive social interaction. There was no statistical correlation between severity of ADHD and salivary OT levels in each of the time points. We conclude that impairments in the reactivity of the OT system in children with ADHD, associated with interpersonal impairments, might be a distinct aspect of the clinical picture, differentiated from the levels of inattentive, hyperactive/impulsive or behavioral symptoms.

Original language	English
Article number	105293
Journal	Psychoneuroendocrinology
Volume	131
DOIs	https://doi.org/10.1016/j.psyneuen.2021.105293
State	Published - Sep 2021

UN SDGs

This output contributes to the following UN Sustainable Development Goals (SDGs)

SDG 3 Good Health and Well-being

Keywords

Attention deficit hyperactivity disorder (ADHD)
Oxytocin
Social cognition

ASJC Scopus subject areas

Endocrinology, Diabetes and Metabolism
Endocrinology
Endocrine and Autonomic Systems
Psychiatry and Mental health
Biological Psychiatry

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10.1016/j.psyneuen.2021.105293

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title = "Lack of association between severity of ADHD symptoms and salivary oxytocin levels",

abstract = "Impairments in the reactivity of Oxytocin (OT) system were associated with interpersonal difficulties in children with ADHD. The current study aimed to explore the correlation between symptoms severity and salivary OT levels at different time-points in children with ADHD. Symptoms severity was assessed in 50 children with ADHD (28 males, mean age 9.42 ± 1.65) using the Swanson, Nolan and Pelham Questionnaire-IV (SNAP-IV) and the Strengths and Difficulties Questionnaire (SDQ). Salivary OT levels were measured at baseline, as well as 15 min after positive social interaction. There was no statistical correlation between severity of ADHD and salivary OT levels in each of the time points. We conclude that impairments in the reactivity of the OT system in children with ADHD, associated with interpersonal impairments, might be a distinct aspect of the clinical picture, differentiated from the levels of inattentive, hyperactive/impulsive or behavioral symptoms.",

keywords = "Attention deficit hyperactivity disorder (ADHD), Oxytocin, Social cognition",

author = "Dennis Boyle and Orit Levi-Shachar and Gvirts, \{Hila Z.\} and Orna Zagoory-Sharon and Ruth Feldman and Yuval Bloch and Uriel Nitzan and Hagai Maoz",

note = "Publisher Copyright: {\textcopyright} 2021 Elsevier Ltd",

year = "2021",

month = sep,

doi = "10.1016/j.psyneuen.2021.105293",

language = "الإنجليزيّة",

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journal = "Psychoneuroendocrinology",

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T1 - Lack of association between severity of ADHD symptoms and salivary oxytocin levels

AU - Boyle, Dennis

AU - Levi-Shachar, Orit

AU - Gvirts, Hila Z.

AU - Zagoory-Sharon, Orna

AU - Feldman, Ruth

AU - Bloch, Yuval

AU - Nitzan, Uriel

AU - Maoz, Hagai

PY - 2021/9

Y1 - 2021/9

N2 - Impairments in the reactivity of Oxytocin (OT) system were associated with interpersonal difficulties in children with ADHD. The current study aimed to explore the correlation between symptoms severity and salivary OT levels at different time-points in children with ADHD. Symptoms severity was assessed in 50 children with ADHD (28 males, mean age 9.42 ± 1.65) using the Swanson, Nolan and Pelham Questionnaire-IV (SNAP-IV) and the Strengths and Difficulties Questionnaire (SDQ). Salivary OT levels were measured at baseline, as well as 15 min after positive social interaction. There was no statistical correlation between severity of ADHD and salivary OT levels in each of the time points. We conclude that impairments in the reactivity of the OT system in children with ADHD, associated with interpersonal impairments, might be a distinct aspect of the clinical picture, differentiated from the levels of inattentive, hyperactive/impulsive or behavioral symptoms.

AB - Impairments in the reactivity of Oxytocin (OT) system were associated with interpersonal difficulties in children with ADHD. The current study aimed to explore the correlation between symptoms severity and salivary OT levels at different time-points in children with ADHD. Symptoms severity was assessed in 50 children with ADHD (28 males, mean age 9.42 ± 1.65) using the Swanson, Nolan and Pelham Questionnaire-IV (SNAP-IV) and the Strengths and Difficulties Questionnaire (SDQ). Salivary OT levels were measured at baseline, as well as 15 min after positive social interaction. There was no statistical correlation between severity of ADHD and salivary OT levels in each of the time points. We conclude that impairments in the reactivity of the OT system in children with ADHD, associated with interpersonal impairments, might be a distinct aspect of the clinical picture, differentiated from the levels of inattentive, hyperactive/impulsive or behavioral symptoms.

KW - Attention deficit hyperactivity disorder (ADHD)

KW - Oxytocin

KW - Social cognition

UR - https://www.scopus.com/pages/publications/85107147948

U2 - 10.1016/j.psyneuen.2021.105293

DO - 10.1016/j.psyneuen.2021.105293

M3 - مقالة

C2 - 34090136

SN - 0306-4530

VL - 131

JO - Psychoneuroendocrinology

JF - Psychoneuroendocrinology

M1 - 105293

ER -

Lack of association between severity of ADHD symptoms and salivary oxytocin levels

Abstract

UN SDGs

Keywords

ASJC Scopus subject areas

Access to Document

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Cite this