Labeling cytosolic targets in live cells with blinking probes

Jianmin Xu, Jason Chang, Qi Yan, Thomas Dertinger, Marcel P. Bruchez, Shimon Weiss

Research output: Contribution to journalReview articlepeer-review


With the advent of superresolution imaging methods, fast dynamic imaging of biological processes in live cells remains a challenge. A subset of these methods requires the cellular targets to be labeled with spontaneously blinking probes. The delivery and specific targeting of cytosolic targets and the control of the probes' blinking properties are reviewed for three types of blinking probes: quantum dots, synthetic dyes, and fluorescent proteins.

Original languageEnglish
Pages (from-to)2138-2146
Number of pages9
JournalJournal of Physical Chemistry Letters
Issue number13
StatePublished - 3 Jul 2013
Externally publishedYes

All Science Journal Classification (ASJC) codes

  • Materials Science(all)
  • Physical and Theoretical Chemistry


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