Kinetics of SARS-CoV-2 anti-S IgG after BNT162b2 vaccination

Daniel Grupel; Sivan Gazit; Licita Schreiber; Varda Nadler; Tamar Wolf; Rachel Lazar; Lia Supino-Rosin; Galit Perez; Asaf Peretz; Amir Ben Tov; Miri Mizrahi-Reuveni; Gabriel Chodick; Tal Patalon

doi:10.1016/j.vaccine.2021.08.025

Kinetics of SARS-CoV-2 anti-S IgG after BNT162b2 vaccination

Daniel Grupel, Sivan Gazit, Licita Schreiber, Varda Nadler, Tamar Wolf, Rachel Lazar, Lia Supino-Rosin, Galit Perez, Asaf Peretz, Amir Ben Tov, Miri Mizrahi-Reuveni, Gabriel Chodick, Tal Patalon

Tel Aviv University, Ben-Gurion University of the Negev

Research output: Contribution to journal › Article › peer-review

Abstract

Deployment of the BNT162b2 mRNA Covid-19 Vaccine in Israel began in December 2020. This is a retrospective analysis of serological data, showing SARS-CoV-2 anti-S IgG kinetics in 116 Israeli health care workers receiving BNT162b2. Sero-conversion occurred in 14 days in all study participants, with IgG levels peaking approximately 30 days after initiation of the vaccination series. A statistically significant difference was observed in IgG levels between subjects younger than 50 years and older participants, although in all cases, IgG levels were well above the level considered reactive by the test's manufacturer. The importance of this difference needs to be studied further, but a potential difference in vaccine efficacy and vaccine effect length could possibly be present between these two groups.

Original language	American English
Pages (from-to)	5337-5340
Number of pages	4
Journal	Vaccine
Volume	39
Issue number	38
DOIs	https://doi.org/10.1016/j.vaccine.2021.08.025
State	Published - 7 Sep 2021

UN SDGs

This output contributes to the following UN Sustainable Development Goals (SDGs)

SDG 3 Good Health and Well-being

Keywords

BNT162b2
IgG kinetics
SARS-CoV-2
Serology

All Science Journal Classification (ASJC) codes

Molecular Medicine
General Immunology and Microbiology
General Veterinary
Public Health, Environmental and Occupational Health
Infectious Diseases

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10.1016/j.vaccine.2021.08.025

Cite this

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title = "Kinetics of SARS-CoV-2 anti-S IgG after BNT162b2 vaccination",

abstract = "Deployment of the BNT162b2 mRNA Covid-19 Vaccine in Israel began in December 2020. This is a retrospective analysis of serological data, showing SARS-CoV-2 anti-S IgG kinetics in 116 Israeli health care workers receiving BNT162b2. Sero-conversion occurred in 14 days in all study participants, with IgG levels peaking approximately 30 days after initiation of the vaccination series. A statistically significant difference was observed in IgG levels between subjects younger than 50 years and older participants, although in all cases, IgG levels were well above the level considered reactive by the test's manufacturer. The importance of this difference needs to be studied further, but a potential difference in vaccine efficacy and vaccine effect length could possibly be present between these two groups.",

keywords = "BNT162b2, IgG kinetics, SARS-CoV-2, Serology",

author = "Daniel Grupel and Sivan Gazit and Licita Schreiber and Varda Nadler and Tamar Wolf and Rachel Lazar and Lia Supino-Rosin and Galit Perez and Asaf Peretz and {Ben Tov}, Amir and Miri Mizrahi-Reuveni and Gabriel Chodick and Tal Patalon",

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doi = "10.1016/j.vaccine.2021.08.025",

language = "American English",

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T1 - Kinetics of SARS-CoV-2 anti-S IgG after BNT162b2 vaccination

AU - Grupel, Daniel

AU - Gazit, Sivan

AU - Schreiber, Licita

AU - Nadler, Varda

AU - Wolf, Tamar

AU - Lazar, Rachel

AU - Supino-Rosin, Lia

AU - Perez, Galit

AU - Peretz, Asaf

AU - Ben Tov, Amir

AU - Mizrahi-Reuveni, Miri

AU - Chodick, Gabriel

AU - Patalon, Tal

PY - 2021/9/7

Y1 - 2021/9/7

N2 - Deployment of the BNT162b2 mRNA Covid-19 Vaccine in Israel began in December 2020. This is a retrospective analysis of serological data, showing SARS-CoV-2 anti-S IgG kinetics in 116 Israeli health care workers receiving BNT162b2. Sero-conversion occurred in 14 days in all study participants, with IgG levels peaking approximately 30 days after initiation of the vaccination series. A statistically significant difference was observed in IgG levels between subjects younger than 50 years and older participants, although in all cases, IgG levels were well above the level considered reactive by the test's manufacturer. The importance of this difference needs to be studied further, but a potential difference in vaccine efficacy and vaccine effect length could possibly be present between these two groups.

AB - Deployment of the BNT162b2 mRNA Covid-19 Vaccine in Israel began in December 2020. This is a retrospective analysis of serological data, showing SARS-CoV-2 anti-S IgG kinetics in 116 Israeli health care workers receiving BNT162b2. Sero-conversion occurred in 14 days in all study participants, with IgG levels peaking approximately 30 days after initiation of the vaccination series. A statistically significant difference was observed in IgG levels between subjects younger than 50 years and older participants, although in all cases, IgG levels were well above the level considered reactive by the test's manufacturer. The importance of this difference needs to be studied further, but a potential difference in vaccine efficacy and vaccine effect length could possibly be present between these two groups.

KW - BNT162b2

KW - IgG kinetics

KW - SARS-CoV-2

KW - Serology

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U2 - 10.1016/j.vaccine.2021.08.025

DO - 10.1016/j.vaccine.2021.08.025

M3 - Article

C2 - 34393018

SN - 0264-410X

VL - 39

SP - 5337

EP - 5340

JO - Vaccine

JF - Vaccine

IS - 38

ER -

Kinetics of SARS-CoV-2 anti-S IgG after BNT162b2 vaccination

Abstract

UN SDGs

Keywords

All Science Journal Classification (ASJC) codes

Access to Document

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