TY - JOUR
T1 - Kidney function and other associated factors of sarcopenia in community-dwelling older adults
T2 - The SCOPE study
AU - Moreno-González, Rafael
AU - Cruzado, Josep Maria
AU - Corsonello, Andrea
AU - Fabbietti, Paolo
AU - Tap, Lisanne
AU - Mattace-Raso, Francesco
AU - Ärnlöv, Johan
AU - Carlsson, Axel C.
AU - Guligowska, Agnieszka
AU - Kostka, Tomasz
AU - Artzi-Medvedik, Rada
AU - Melzer, Itshak
AU - Roller-Wirnsberger, Regina
AU - Wirnsberger, Gerhard
AU - Kob, Robert
AU - Sieber, Cornel
AU - Lattanzio, Fabrizia
AU - Formiga, Francesc
N1 - Publisher Copyright: © 2023
PY - 2024/5/1
Y1 - 2024/5/1
N2 - Aim: Sarcopenia is associated with several factors and medical conditions among older adults, though previous research has shown limitations and inconsistencies, especially regarding chronic kidney disease (CKD). We investigated the clinical and laboratory variables associated with sarcopenia and severe sarcopenia in older adults, focusing on kidney function measures. Methods: Data from community-dwelling adults aged ≥75 years participating in the SCOPE multicenter prospective cohort study were assessed cross-sectionally. Comprehensive geriatric assessment was conducted; sociodemographic and lifestyle factors, clinical variables and comorbidities, anthropometric and bioelectrical impedance analysis, blood and urine laboratory variables were collected. EWGSOP2 revised criteria were used to define sarcopenia and its severity. Estimated glomerular filtration rate (eGFR) was calculated using creatinine and non-creatinine-based equations, and CKD stages were defined accordingly. Results: 1420 participants were included, prevalence of sarcopenia was 10.6 %, and 6 % had severe sarcopenia. Multivariate logistic regression analysis showed that age [OR =1.14; 95 %CI (1.09–1.19)], body mass index (BMI) [0.83 (0.79–0.88)], disability performing instrumental activities of daily living (IADL) [2.61 (1.69–4.06)], Mini Mental State Examination (MMSE) score <24 [2.75 (1.62–4.67)], osteoporosis [2.39 (1.55–3.67)], and stage 4 CKD defined by CKD-EPIBTP-B2M, a non-creatinine-based eGFR equation [2.88 (1.11–7.49)], were independently associated with sarcopenia; as were specifically with severe sarcopenia, with more pronounced associations. Conclusions: In community-dwelling older adults, sarcopenia is a relevant condition and is associated with severe CKD, older age, IADL, cognitive impairments, osteoporosis and low BMI. These factors should be assessed for proper identification and management of older patients with sarcopenia, and even more so with severe sarcopenia.
AB - Aim: Sarcopenia is associated with several factors and medical conditions among older adults, though previous research has shown limitations and inconsistencies, especially regarding chronic kidney disease (CKD). We investigated the clinical and laboratory variables associated with sarcopenia and severe sarcopenia in older adults, focusing on kidney function measures. Methods: Data from community-dwelling adults aged ≥75 years participating in the SCOPE multicenter prospective cohort study were assessed cross-sectionally. Comprehensive geriatric assessment was conducted; sociodemographic and lifestyle factors, clinical variables and comorbidities, anthropometric and bioelectrical impedance analysis, blood and urine laboratory variables were collected. EWGSOP2 revised criteria were used to define sarcopenia and its severity. Estimated glomerular filtration rate (eGFR) was calculated using creatinine and non-creatinine-based equations, and CKD stages were defined accordingly. Results: 1420 participants were included, prevalence of sarcopenia was 10.6 %, and 6 % had severe sarcopenia. Multivariate logistic regression analysis showed that age [OR =1.14; 95 %CI (1.09–1.19)], body mass index (BMI) [0.83 (0.79–0.88)], disability performing instrumental activities of daily living (IADL) [2.61 (1.69–4.06)], Mini Mental State Examination (MMSE) score <24 [2.75 (1.62–4.67)], osteoporosis [2.39 (1.55–3.67)], and stage 4 CKD defined by CKD-EPIBTP-B2M, a non-creatinine-based eGFR equation [2.88 (1.11–7.49)], were independently associated with sarcopenia; as were specifically with severe sarcopenia, with more pronounced associations. Conclusions: In community-dwelling older adults, sarcopenia is a relevant condition and is associated with severe CKD, older age, IADL, cognitive impairments, osteoporosis and low BMI. These factors should be assessed for proper identification and management of older patients with sarcopenia, and even more so with severe sarcopenia.
KW - Chronic kidney disease
KW - Estimated glomerular filtration rate
KW - Kidney function
KW - Older adults
KW - Sarcopenia
KW - Severe sarcopenia
UR - http://www.scopus.com/inward/record.url?scp=85180742900&partnerID=8YFLogxK
U2 - 10.1016/j.ejim.2023.12.002
DO - 10.1016/j.ejim.2023.12.002
M3 - Article
C2 - 38103954
SN - 0953-6205
VL - 123
SP - 81
EP - 93
JO - European Journal of Internal Medicine
JF - European Journal of Internal Medicine
ER -
