Juvenile adversity and adult threat controllability in translational models of stress-related disorders

Gilad Ritov, Ziv Ardi, Omer Horovitz, Anne Albrecht, Gal Richter-Levin

Research output: Contribution to journalReview articlepeer-review

Abstract

Only some individuals exposed to a traumatic experience eventually develop stress-related disorders such as anxiety and PTSD, indicating that the development and course of such disorders are influenced considerably by different risk factors. Understanding the way such risk factors contribute to the development of pathology is thus a key issue in understanding the neurobiology of stress-related disorders. Here we review behavioral approaches and evidence from recent studies which utilized innovative fear conditioning procedures in rats aiming to model pre- and peri-exposure risk factors, including pre-exposure to pre-pubertal adversities, and the level of controllability over the stressful experience during the exposure to the trauma. Furthermore, the importance of taking into consideration individual variability in post-exposure stress-related behaviors in order to differentiate between exposed-affected and exposed-unaffected individuals is demonstrated.

Original languageAmerican English
Pages (from-to)148-154
Number of pages7
JournalCurrent Opinion in Behavioral Sciences
Volume14
DOIs
StatePublished - 1 Apr 2017

All Science Journal Classification (ASJC) codes

  • Psychiatry and Mental health
  • Cognitive Neuroscience
  • Behavioral Neuroscience

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