Isotope Labeling Study of Retinal Chromophore Fragmentation

Lihi Musbat; Maria Nihamkin; Shany Ytzhak; Amiram Hirshfeld; Noga Friedman; Jonathan M. Dilger; Mordechai Sheves; Yoni Toker

doi:10.1021/acs.jpca.6b02525

Isotope Labeling Study of Retinal Chromophore Fragmentation

Lihi Musbat, Maria Nihamkin, Shany Ytzhak, Amiram Hirshfeld, Noga Friedman, Jonathan M. Dilger, Mordechai Sheves, Yoni Toker

Bar-Ilan University, Weizmann Institute of Science

Research output: Contribution to journal › Article › peer-review

Abstract

Previous studies have shown that the gas-phase fragmentation of the retinal chromophore after S0-S1 photoexcitation results in a prominent fragment of mass 248 which cannot be explained by the cleavage of any single bond along the polyene chain. It was therefore theorized that the fragmentation mechanism involves a series of isomerizations and cyclization processes, and two mechanisms for these processes were suggested. Here we used isotope labeling MS-MS to provide conclusive support for the fragmentation mechanism suggested by Coughlan et al. (J. Phys. Chem. Lett. 2014, 5, 3195).

Original language	English
Pages (from-to)	2547-2549
Number of pages	3
Journal	Journal of Physical Chemistry A
Volume	120
Issue number	16
Early online date	18 Apr 2016
DOIs	https://doi.org/10.1021/acs.jpca.6b02525
State	Published - 28 Apr 2016

All Science Journal Classification (ASJC) codes

Physical and Theoretical Chemistry

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10.1021/acs.jpca.6b02525

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title = "Isotope Labeling Study of Retinal Chromophore Fragmentation",

abstract = "Previous studies have shown that the gas-phase fragmentation of the retinal chromophore after S0-S1 photoexcitation results in a prominent fragment of mass 248 which cannot be explained by the cleavage of any single bond along the polyene chain. It was therefore theorized that the fragmentation mechanism involves a series of isomerizations and cyclization processes, and two mechanisms for these processes were suggested. Here we used isotope labeling MS-MS to provide conclusive support for the fragmentation mechanism suggested by Coughlan et al. (J. Phys. Chem. Lett. 2014, 5, 3195).",

author = "Lihi Musbat and Maria Nihamkin and Shany Ytzhak and Amiram Hirshfeld and Noga Friedman and Dilger, \{Jonathan M.\} and Mordechai Sheves and Yoni Toker",

note = "Publisher Copyright: {\textcopyright} 2016 American Chemical Society.",

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doi = "10.1021/acs.jpca.6b02525",

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T1 - Isotope Labeling Study of Retinal Chromophore Fragmentation

AU - Musbat, Lihi

AU - Nihamkin, Maria

AU - Ytzhak, Shany

AU - Hirshfeld, Amiram

AU - Friedman, Noga

AU - Dilger, Jonathan M.

AU - Sheves, Mordechai

AU - Toker, Yoni

PY - 2016/4/28

Y1 - 2016/4/28

N2 - Previous studies have shown that the gas-phase fragmentation of the retinal chromophore after S0-S1 photoexcitation results in a prominent fragment of mass 248 which cannot be explained by the cleavage of any single bond along the polyene chain. It was therefore theorized that the fragmentation mechanism involves a series of isomerizations and cyclization processes, and two mechanisms for these processes were suggested. Here we used isotope labeling MS-MS to provide conclusive support for the fragmentation mechanism suggested by Coughlan et al. (J. Phys. Chem. Lett. 2014, 5, 3195).

AB - Previous studies have shown that the gas-phase fragmentation of the retinal chromophore after S0-S1 photoexcitation results in a prominent fragment of mass 248 which cannot be explained by the cleavage of any single bond along the polyene chain. It was therefore theorized that the fragmentation mechanism involves a series of isomerizations and cyclization processes, and two mechanisms for these processes were suggested. Here we used isotope labeling MS-MS to provide conclusive support for the fragmentation mechanism suggested by Coughlan et al. (J. Phys. Chem. Lett. 2014, 5, 3195).

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U2 - 10.1021/acs.jpca.6b02525

DO - 10.1021/acs.jpca.6b02525

M3 - مقالة

C2 - 27046667

SN - 1089-5639

VL - 120

SP - 2547

EP - 2549

JO - Journal of Physical Chemistry A

JF - Journal of Physical Chemistry A

IS - 16

ER -

Isotope Labeling Study of Retinal Chromophore Fragmentation

Abstract

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