Isolated Glucosuria in Adolescence and Early-Onset Diabetes: A Nationwide Cohort Study of 1.6 Million Adolescents

Adi Vinograd; Tsahi T. Lerman; Orit Pinhas-Hamiel; Aya Bardugo; Cole D. Bendor; Estela Derazne; Josef Coresh; Ofir Vinograd; Miri Lutski; Inbar Zucker; Michal Bromberg; Tamar Fishman; Gabriel Chodick; Hertzel C. Gerstein; Tali Cukierman-Yaffe; Asaf Vivante; Adi Leiba; Arnon Afek; Amir Tirosh; Boris Fishman; Gilad Twig

doi:10.2337/dc24-2402

Isolated Glucosuria in Adolescence and Early-Onset Diabetes: A Nationwide Cohort Study of 1.6 Million Adolescents

Adi Vinograd, Tsahi T. Lerman, Orit Pinhas-Hamiel, Aya Bardugo, Cole D. Bendor, Estela Derazne, Josef Coresh, Ofir Vinograd, Miri Lutski, Inbar Zucker, Michal Bromberg, Tamar Fishman, Gabriel Chodick, Hertzel C. Gerstein, Tali Cukierman-Yaffe, Asaf Vivante, Adi Leiba, Arnon Afek, Amir Tirosh, Boris FishmanGilad Twig

Ben-Gurion University of the Negev, Tel Aviv University

Research output: Contribution to journal › Article › peer-review

Abstract

OBJECTIVE: We assess diabetes risk in adulthood among adolescents with isolated glucosuria. RESEARCH DESIGN AND METHODS: Included were adolescents (16-19 years) examined before military service between 1993 and 2015. Data were linked with the Israeli National Diabetes Registry. Glucosuria was confirmed following normal renal function and glucose tolerance tests. Cox models were applied. RESULTS: The study included 1,611,467 adolescents, of whom 755 (0.05%) had glucosuria. The latter group had a higher proportion of males (75% vs. 57%) and a lower proportion of BMI ≥ 85th percentile (10.4% vs. 16.3%) compared with nonglucosuric (all P < 0.001). During follow-up, 10,328 diabetes cases were recorded with an incidence rate of 87.5 and 43.3 per 100,000 person-years for those with versus without glucosuria, respectively. Individuals with glucosuria had an adjusted hazard ratio of 2.17 (95% CI, 1.17-4.04) for diabetes. CONCLUSIONS: Glucosuria in adolescents is associated with an increased risk of early-onset diabetes.

Original language	American English
Pages (from-to)	763-767
Number of pages	5
Journal	Diabetes Care
Volume	48
Issue number	5
DOIs	https://doi.org/10.2337/dc24-2402
State	Published - 1 May 2025

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SDG 3 Good Health and Well-being

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Internal Medicine
Endocrinology, Diabetes and Metabolism
Advanced and Specialised Nursing

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10.2337/dc24-2402

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Vinograd, A., Lerman, T. T., Pinhas-Hamiel, O., Bardugo, A., Bendor, C. D., Derazne, E., Coresh, J., Vinograd, O., Lutski, M., Zucker, I., Bromberg, M., Fishman, T., Chodick, G., Gerstein, H. C., Cukierman-Yaffe, T., Vivante, A., Leiba, A., Afek, A., Tirosh, A., ... Twig, G. (2025). Isolated Glucosuria in Adolescence and Early-Onset Diabetes: A Nationwide Cohort Study of 1.6 Million Adolescents. Diabetes Care, 48(5), 763-767. https://doi.org/10.2337/dc24-2402

@article{e56a44f41d5d4dacaf16db37dee94fdc,

title = "Isolated Glucosuria in Adolescence and Early-Onset Diabetes: A Nationwide Cohort Study of 1.6 Million Adolescents",

abstract = "OBJECTIVE: We assess diabetes risk in adulthood among adolescents with isolated glucosuria. RESEARCH DESIGN AND METHODS: Included were adolescents (16-19 years) examined before military service between 1993 and 2015. Data were linked with the Israeli National Diabetes Registry. Glucosuria was confirmed following normal renal function and glucose tolerance tests. Cox models were applied. RESULTS: The study included 1,611,467 adolescents, of whom 755 (0.05\%) had glucosuria. The latter group had a higher proportion of males (75\% vs. 57\%) and a lower proportion of BMI ≥ 85th percentile (10.4\% vs. 16.3\%) compared with nonglucosuric (all P < 0.001). During follow-up, 10,328 diabetes cases were recorded with an incidence rate of 87.5 and 43.3 per 100,000 person-years for those with versus without glucosuria, respectively. Individuals with glucosuria had an adjusted hazard ratio of 2.17 (95\% CI, 1.17-4.04) for diabetes. CONCLUSIONS: Glucosuria in adolescents is associated with an increased risk of early-onset diabetes.",

author = "Adi Vinograd and Lerman, \{Tsahi T.\} and Orit Pinhas-Hamiel and Aya Bardugo and Bendor, \{Cole D.\} and Estela Derazne and Josef Coresh and Ofir Vinograd and Miri Lutski and Inbar Zucker and Michal Bromberg and Tamar Fishman and Gabriel Chodick and Gerstein, \{Hertzel C.\} and Tali Cukierman-Yaffe and Asaf Vivante and Adi Leiba and Arnon Afek and Amir Tirosh and Boris Fishman and Gilad Twig",

note = "Publisher Copyright: {\textcopyright} 2025 by the American Diabetes Association.",

year = "2025",

month = may,

day = "1",

doi = "10.2337/dc24-2402",

language = "American English",

volume = "48",

pages = "763--767",

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Vinograd, A, Lerman, TT, Pinhas-Hamiel, O, Bardugo, A, Bendor, CD, Derazne, E, Coresh, J, Vinograd, O, Lutski, M, Zucker, I, Bromberg, M, Fishman, T, Chodick, G, Gerstein, HC, Cukierman-Yaffe, T, Vivante, A, Leiba, A, Afek, A, Tirosh, A, Fishman, B & Twig, G 2025, 'Isolated Glucosuria in Adolescence and Early-Onset Diabetes: A Nationwide Cohort Study of 1.6 Million Adolescents', Diabetes Care, vol. 48, no. 5, pp. 763-767. https://doi.org/10.2337/dc24-2402

TY - JOUR

T1 - Isolated Glucosuria in Adolescence and Early-Onset Diabetes

T2 - A Nationwide Cohort Study of 1.6 Million Adolescents

AU - Vinograd, Adi

AU - Lerman, Tsahi T.

AU - Pinhas-Hamiel, Orit

AU - Bardugo, Aya

AU - Bendor, Cole D.

AU - Derazne, Estela

AU - Coresh, Josef

AU - Vinograd, Ofir

AU - Lutski, Miri

AU - Zucker, Inbar

AU - Bromberg, Michal

AU - Fishman, Tamar

AU - Chodick, Gabriel

AU - Gerstein, Hertzel C.

AU - Cukierman-Yaffe, Tali

AU - Vivante, Asaf

AU - Leiba, Adi

AU - Afek, Arnon

AU - Tirosh, Amir

AU - Fishman, Boris

AU - Twig, Gilad

PY - 2025/5/1

Y1 - 2025/5/1

N2 - OBJECTIVE: We assess diabetes risk in adulthood among adolescents with isolated glucosuria. RESEARCH DESIGN AND METHODS: Included were adolescents (16-19 years) examined before military service between 1993 and 2015. Data were linked with the Israeli National Diabetes Registry. Glucosuria was confirmed following normal renal function and glucose tolerance tests. Cox models were applied. RESULTS: The study included 1,611,467 adolescents, of whom 755 (0.05%) had glucosuria. The latter group had a higher proportion of males (75% vs. 57%) and a lower proportion of BMI ≥ 85th percentile (10.4% vs. 16.3%) compared with nonglucosuric (all P < 0.001). During follow-up, 10,328 diabetes cases were recorded with an incidence rate of 87.5 and 43.3 per 100,000 person-years for those with versus without glucosuria, respectively. Individuals with glucosuria had an adjusted hazard ratio of 2.17 (95% CI, 1.17-4.04) for diabetes. CONCLUSIONS: Glucosuria in adolescents is associated with an increased risk of early-onset diabetes.

AB - OBJECTIVE: We assess diabetes risk in adulthood among adolescents with isolated glucosuria. RESEARCH DESIGN AND METHODS: Included were adolescents (16-19 years) examined before military service between 1993 and 2015. Data were linked with the Israeli National Diabetes Registry. Glucosuria was confirmed following normal renal function and glucose tolerance tests. Cox models were applied. RESULTS: The study included 1,611,467 adolescents, of whom 755 (0.05%) had glucosuria. The latter group had a higher proportion of males (75% vs. 57%) and a lower proportion of BMI ≥ 85th percentile (10.4% vs. 16.3%) compared with nonglucosuric (all P < 0.001). During follow-up, 10,328 diabetes cases were recorded with an incidence rate of 87.5 and 43.3 per 100,000 person-years for those with versus without glucosuria, respectively. Individuals with glucosuria had an adjusted hazard ratio of 2.17 (95% CI, 1.17-4.04) for diabetes. CONCLUSIONS: Glucosuria in adolescents is associated with an increased risk of early-onset diabetes.

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U2 - 10.2337/dc24-2402

DO - 10.2337/dc24-2402

M3 - Article

C2 - 40009774

SN - 1935-5548

VL - 48

SP - 763

EP - 767

JO - Diabetes Care

JF - Diabetes Care

IS - 5

ER -

Isolated Glucosuria in Adolescence and Early-Onset Diabetes: A Nationwide Cohort Study of 1.6 Million Adolescents

Abstract

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