Is Progressive Chronic Kidney Disease a Slow Acute Kidney Injury?

Larry D. Cowgill, David J. Polzin, Jonathan Elliott, Mary B. Nabity, Gilad Segev, Gregory F. Grauer, Scott Brown, Cathy Langston, Astrid M. van Dongen

Research output: Contribution to journalReview articlepeer-review


International Renal Interest Society chronic kidney disease Stage 1 and acute kidney injury Grade I categorizations of kidney disease are often confused or ignored because patients are nonazotemic and generally asymptomatic. Recent evidence suggests these seemingly disparate conditions may be mechanistically linked and interrelated. Active kidney injury biomarkers have the potential to establish a new understanding for traditional views of chronic kidney disease, including its early identification and possible mediators of its progression, which, if validated, would establish a new and sophisticated paradigm for the understanding and approach to the diagnostic evaluation, and treatment of urinary disease in dogs and cats.

Original languageAmerican English
Pages (from-to)995-1013
Number of pages19
JournalVeterinary Clinics of North America - Small Animal Practice
Issue number6
StatePublished - 1 Nov 2016


  • IRIS AKI grade I
  • IRIS CKD stage 1
  • Kidney biomarkers
  • Progressive chronic kidney disease

All Science Journal Classification (ASJC) codes

  • Small Animals


Dive into the research topics of 'Is Progressive Chronic Kidney Disease a Slow Acute Kidney Injury?'. Together they form a unique fingerprint.

Cite this