Is clathrin a membrane fission protein?

Ling Gang Wu; Lisi Wei; Michael M. Kozlov

doi:10.1016/j.tcb.2025.03.005

Is clathrin a membrane fission protein?

Ling Gang Wu, Lisi Wei, Michael M. Kozlov

Physiology Pharmacology

Tel Aviv University

Research output: Contribution to journal › Short survey › peer-review

Abstract

Membrane fission is thought to involve helix-forming proteins to constrict the Ω-shaped profile's neck. Recent studies suggest that membrane pit-coating proteins, especially clathrin, may also mediate fission via polymerization on the Ω-profile's base or head to generate neck constriction, which underlies various endocytic modes previously attributed as clathrin (Ω-profile head) independent.

Original language	English
Journal	Trends in Cell Biology
DOIs	https://doi.org/10.1016/j.tcb.2025.03.005
State	Accepted/In press - 2025

Keywords

clathrin
endocytosis
kiss-and-run fusion
membrane coat proteins
membrane fission
transmitter release

All Science Journal Classification (ASJC) codes

Cell Biology

Access to Document

10.1016/j.tcb.2025.03.005

Cite this

@article{11f4cda6f26f4b5e932125a01657fcb8,

title = "Is clathrin a membrane fission protein?",

abstract = "Membrane fission is thought to involve helix-forming proteins to constrict the Ω-shaped profile's neck. Recent studies suggest that membrane pit-coating proteins, especially clathrin, may also mediate fission via polymerization on the Ω-profile's base or head to generate neck constriction, which underlies various endocytic modes previously attributed as clathrin (Ω-profile head) independent.",

keywords = "clathrin, endocytosis, kiss-and-run fusion, membrane coat proteins, membrane fission, transmitter release",

author = "Wu, {Ling Gang} and Lisi Wei and Kozlov, {Michael M.}",

note = "Publisher Copyright: {\textcopyright} 2025",

year = "2025",

doi = "10.1016/j.tcb.2025.03.005",

language = "الإنجليزيّة",

journal = "Trends in Cell Biology",