ION EXCHANGERS AND METHODS OF USE THEREOF

Israel Sekler; Michal Hershfinkel; Yoram Yagil; Raz Palty

ION EXCHANGERS AND METHODS OF USE THEREOF

Israel Sekler (Inventor), Michal Hershfinkel (Inventor), Yoram Yagil (Inventor), Raz Palty (Inventor)

Research output: Patent

Abstract

This invention provides a method of treating a disease by stimulating or accelerating calcium flux via a mitochondrial Na+/Ca2+ NCLX exchanger. This invention further provides a method of treating a disease by diminishing or abrogating calcium flux via a mitochondrial Na+/Ca2+ NCLX exchanger. This invention also provides compounds and compositions comprising the same for diminishing or abrogating mitochondrial Na+/Ca2+-Li+ exchanger (NCLX) expression or activity, thereby inhibiting apoptosis, or for stimulating or increasing mitochondrial Na+/Ca2+ NCLX exchanger expression or activity, thereby stimulating or accelerating apoptosis. This invention further provides compounds and compositions comprising the same for modulating apoptosis and treating diseases, disorders and/or conditions related thereto.

Original language	American English
Patent number	WO2011048589
IPC	A61K 48/ 00 A I
Priority date	23/10/09
State	Published - 28 Apr 2011

Cite this

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title = "ION EXCHANGERS AND METHODS OF USE THEREOF",

abstract = "This invention provides a method of treating a disease by stimulating or accelerating calcium flux via a mitochondrial Na+/Ca2+ NCLX exchanger. This invention further provides a method of treating a disease by diminishing or abrogating calcium flux via a mitochondrial Na+/Ca2+ NCLX exchanger. This invention also provides compounds and compositions comprising the same for diminishing or abrogating mitochondrial Na+/Ca2+-Li+ exchanger (NCLX) expression or activity, thereby inhibiting apoptosis, or for stimulating or increasing mitochondrial Na+/Ca2+ NCLX exchanger expression or activity, thereby stimulating or accelerating apoptosis. This invention further provides compounds and compositions comprising the same for modulating apoptosis and treating diseases, disorders and/or conditions related thereto.",

author = "Israel Sekler and Michal Hershfinkel and Yoram Yagil and Raz Palty",

year = "2011",

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language = "American English",

type = "Patent",

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TY - PAT

T1 - ION EXCHANGERS AND METHODS OF USE THEREOF

AU - Sekler, Israel

AU - Hershfinkel, Michal

AU - Yagil, Yoram

AU - Palty, Raz

PY - 2011/4/28

Y1 - 2011/4/28

N2 - This invention provides a method of treating a disease by stimulating or accelerating calcium flux via a mitochondrial Na+/Ca2+ NCLX exchanger. This invention further provides a method of treating a disease by diminishing or abrogating calcium flux via a mitochondrial Na+/Ca2+ NCLX exchanger. This invention also provides compounds and compositions comprising the same for diminishing or abrogating mitochondrial Na+/Ca2+-Li+ exchanger (NCLX) expression or activity, thereby inhibiting apoptosis, or for stimulating or increasing mitochondrial Na+/Ca2+ NCLX exchanger expression or activity, thereby stimulating or accelerating apoptosis. This invention further provides compounds and compositions comprising the same for modulating apoptosis and treating diseases, disorders and/or conditions related thereto.

AB - This invention provides a method of treating a disease by stimulating or accelerating calcium flux via a mitochondrial Na+/Ca2+ NCLX exchanger. This invention further provides a method of treating a disease by diminishing or abrogating calcium flux via a mitochondrial Na+/Ca2+ NCLX exchanger. This invention also provides compounds and compositions comprising the same for diminishing or abrogating mitochondrial Na+/Ca2+-Li+ exchanger (NCLX) expression or activity, thereby inhibiting apoptosis, or for stimulating or increasing mitochondrial Na+/Ca2+ NCLX exchanger expression or activity, thereby stimulating or accelerating apoptosis. This invention further provides compounds and compositions comprising the same for modulating apoptosis and treating diseases, disorders and/or conditions related thereto.

M3 - Patent

M1 - WO2011048589

ER -