ION EXCHANGERS AND METHODS OF USE THEREOF

Israel Sekler (Inventor), Michal Hershfinkel (Inventor), Yoram Yagil (Inventor), Raz Palty (Inventor)

Research output: Patent

Abstract

This invention provides a method of treating a disease by stimulating or accelerating calcium flux via a mitochondrial Na+/Ca2+ NCLX exchanger. This invention further provides a method of treating a disease by diminishing or abrogating calcium flux via a mitochondrial Na+/Ca2+ NCLX exchanger. This invention also provides compounds and compositions comprising the same for diminishing or abrogating mitochondrial Na+/Ca2+-Li+ exchanger (NCLX) expression or activity, thereby inhibiting apoptosis, or for stimulating or increasing mitochondrial Na+/Ca2+ NCLX exchanger expression or activity, thereby stimulating or accelerating apoptosis. This invention further provides compounds and compositions comprising the same for modulating apoptosis and treating diseases, disorders and/or conditions related thereto.

Original languageAmerican English
Patent numberWO2011048589
IPCA61K 48/ 00 A I
Priority date23/10/09
StatePublished - 28 Apr 2011

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