Intrinsically Disordered Regions Direct Transcription Factor In Vivo Binding Specificity

Sagie Brodsky; Tamar Jana; Karin Mittelman; Michal Chapal; Divya Krishna Kumar; Miri Carmi; Naama Barkai

doi:10.1016/j.molcel.2020.05.032

Intrinsically Disordered Regions Direct Transcription Factor In Vivo Binding Specificity

Sagie Brodsky, Tamar Jana, Karin Mittelman, Michal Chapal, Divya Krishna Kumar, Miri Carmi, Naama Barkai

Research output: Contribution to journal › Article › peer-review

Abstract

Transcription factors (TFs) bind only a subset of their motif-containing promoters. Brodsky and Jana et al. find that promoter selection is dictated by multiple specificity determinants distributed across long intrinsically disordered regions (IDRs) encoded within the TF sequence. IDR-guided specificity may accelerate binding-site recognition by an initial detection of broad DNA regions.

Original language	English
Pages (from-to)	459-471.e4
Journal	Molecular Cell
Volume	79
Issue number	3
DOIs	https://doi.org/10.1016/j.molcel.2020.05.032
State	Published - 6 Aug 2020
Externally published	Yes

Keywords

DNA binding
intrinsically disordered proteins
intrinsically disordered regions
transcription factors

All Science Journal Classification (ASJC) codes

Molecular Biology
Cell Biology

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10.1016/j.molcel.2020.05.032

Cite this

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title = "Intrinsically Disordered Regions Direct Transcription Factor In Vivo Binding Specificity",

abstract = "Transcription factors (TFs) bind only a subset of their motif-containing promoters. Brodsky and Jana et al. find that promoter selection is dictated by multiple specificity determinants distributed across long intrinsically disordered regions (IDRs) encoded within the TF sequence. IDR-guided specificity may accelerate binding-site recognition by an initial detection of broad DNA regions.",

keywords = "DNA binding, intrinsically disordered proteins, intrinsically disordered regions, transcription factors",

author = "Sagie Brodsky and Tamar Jana and Karin Mittelman and Michal Chapal and Kumar, \{Divya Krishna\} and Miri Carmi and Naama Barkai",

note = "Publisher Copyright: {\textcopyright} 2020 Elsevier Inc.",

year = "2020",

month = aug,

day = "6",

doi = "10.1016/j.molcel.2020.05.032",

language = "الإنجليزيّة",

volume = "79",

pages = "459--471.e4",

journal = "Molecular Cell",

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TY - JOUR

T1 - Intrinsically Disordered Regions Direct Transcription Factor In Vivo Binding Specificity

AU - Brodsky, Sagie

AU - Jana, Tamar

AU - Mittelman, Karin

AU - Chapal, Michal

AU - Kumar, Divya Krishna

AU - Carmi, Miri

AU - Barkai, Naama

PY - 2020/8/6

Y1 - 2020/8/6

N2 - Transcription factors (TFs) bind only a subset of their motif-containing promoters. Brodsky and Jana et al. find that promoter selection is dictated by multiple specificity determinants distributed across long intrinsically disordered regions (IDRs) encoded within the TF sequence. IDR-guided specificity may accelerate binding-site recognition by an initial detection of broad DNA regions.

AB - Transcription factors (TFs) bind only a subset of their motif-containing promoters. Brodsky and Jana et al. find that promoter selection is dictated by multiple specificity determinants distributed across long intrinsically disordered regions (IDRs) encoded within the TF sequence. IDR-guided specificity may accelerate binding-site recognition by an initial detection of broad DNA regions.

KW - DNA binding

KW - intrinsically disordered proteins

KW - intrinsically disordered regions

KW - transcription factors

UR - http://www.scopus.com/inward/record.url?scp=85088857975&partnerID=8YFLogxK

U2 - 10.1016/j.molcel.2020.05.032

DO - 10.1016/j.molcel.2020.05.032

M3 - مقالة

C2 - 32553192

SN - 1097-2765

VL - 79

SP - 459-471.e4

JO - Molecular Cell

JF - Molecular Cell

IS - 3

ER -

Intrinsically Disordered Regions Direct Transcription Factor In Vivo Binding Specificity

Abstract

Keywords

All Science Journal Classification (ASJC) codes

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