Intratumoral bacteria may elicit chemoresistance by metabolizing anticancer agents

Leore T. Geller, Ravid Straussman

Research output: Contribution to journalArticlepeer-review

Abstract

We recently reported that bacteria can be found within pancreatic ductal adenocarcinoma (PDAC) tumors. Some of these bacteria can metabolize and thereby inactivate the nucleoside analog gemcitabine. We demonstrated that the long isoform of the bacterial enzyme cytidine deaminase (CDD) mediates the metabolism of gemcitabine. The clinical effect of overcoming this potential mechanism of drug resistance has yet to be studied.

Original languageEnglish
Article numbere1405139
Number of pages3
JournalMolecular and Cellular Oncology
Volume5
Issue number1
DOIs
StatePublished - Jan 2018

All Science Journal Classification (ASJC) codes

  • Molecular Medicine
  • Cancer Research

Fingerprint

Dive into the research topics of 'Intratumoral bacteria may elicit chemoresistance by metabolizing anticancer agents'. Together they form a unique fingerprint.

Cite this