Intra-Tumoral Metabolic Zonation and Resultant Phenotypic Diversification Are Dictated by Blood Vessel Proximity

Saran Kumar; Husni Sharife; Tirzah Kreisel; Maxim Mogilevsky; Libat Bar-Lev; Myriam Grunewald; Elina Aizenshtein; Rotem Karni; Iddo Paldor; Tomer Shlomi; Eli Keshet

doi:https://doi.org/10.1016/j.cmet.2019.04.003

Intra-Tumoral Metabolic Zonation and Resultant Phenotypic Diversification Are Dictated by Blood Vessel Proximity

Saran Kumar, Husni Sharife, Tirzah Kreisel, Maxim Mogilevsky, Libat Bar-Lev, Myriam Grunewald, Elina Aizenshtein, Rotem Karni, Iddo Paldor, Tomer Shlomi, Eli Keshet

The Hebrew University of Jerusalem, Technion - Israel Institute of Technology

Research output: Contribution to journal › Article › peer-review

Abstract

Kumar et al. report a previously unappreciated level of metabolic zonation within glioblastoma tumors dictated by the relative distance from blood vessels. This metabolic zonation leads to position-dependent functional heterogeneity. Proximity to perfused vessels endows a “privileged” perivascular tier with a distinctive mTOR-dominated anabolic metabolism, enhanced cancer aggressiveness, and superior resistance to chemo- and radiotherapy.

Original language	English
Pages (from-to)	201-211.e6
Journal	Cell Metabolism
Volume	30
Issue number	1
DOIs	https://doi.org/10.1016/j.cmet.2019.04.003
State	Published - 2 Jul 2019

Keywords

blood vessels
glioblastoma
mTOR pathway
metabolic compartmentalization
tumor heterogeneity
tumor microenvironment
tumor vasculature

All Science Journal Classification (ASJC) codes

Physiology
Molecular Biology
Cell Biology

UN SDGs

This output contributes to the following UN Sustainable Development Goals (SDGs)

Access to Document

https://doi.org/10.1016/j.cmet.2019.04.003

Cite this

@article{02f7bac894a14a3d8f7819c799616cba,

title = "Intra-Tumoral Metabolic Zonation and Resultant Phenotypic Diversification Are Dictated by Blood Vessel Proximity",

abstract = "Kumar et al. report a previously unappreciated level of metabolic zonation within glioblastoma tumors dictated by the relative distance from blood vessels. This metabolic zonation leads to position-dependent functional heterogeneity. Proximity to perfused vessels endows a “privileged” perivascular tier with a distinctive mTOR-dominated anabolic metabolism, enhanced cancer aggressiveness, and superior resistance to chemo- and radiotherapy.",

keywords = "blood vessels, glioblastoma, mTOR pathway, metabolic compartmentalization, tumor heterogeneity, tumor microenvironment, tumor vasculature",

author = "Saran Kumar and Husni Sharife and Tirzah Kreisel and Maxim Mogilevsky and Libat Bar-Lev and Myriam Grunewald and Elina Aizenshtein and Rotem Karni and Iddo Paldor and Tomer Shlomi and Eli Keshet",

note = "Publisher Copyright: {\textcopyright} 2019 Elsevier Inc.",

year = "2019",

month = jul,

day = "2",

doi = "https://doi.org/10.1016/j.cmet.2019.04.003",

language = "الإنجليزيّة",

volume = "30",

pages = "201--211.e6",

journal = "Cell Metabolism",

issn = "1550-4131",

publisher = "Cell Press",

number = "1",

}

TY - JOUR

T1 - Intra-Tumoral Metabolic Zonation and Resultant Phenotypic Diversification Are Dictated by Blood Vessel Proximity

AU - Kumar, Saran

AU - Sharife, Husni

AU - Kreisel, Tirzah

AU - Mogilevsky, Maxim

AU - Bar-Lev, Libat

AU - Grunewald, Myriam

AU - Aizenshtein, Elina

AU - Karni, Rotem

AU - Paldor, Iddo

AU - Shlomi, Tomer

AU - Keshet, Eli

PY - 2019/7/2

Y1 - 2019/7/2

N2 - Kumar et al. report a previously unappreciated level of metabolic zonation within glioblastoma tumors dictated by the relative distance from blood vessels. This metabolic zonation leads to position-dependent functional heterogeneity. Proximity to perfused vessels endows a “privileged” perivascular tier with a distinctive mTOR-dominated anabolic metabolism, enhanced cancer aggressiveness, and superior resistance to chemo- and radiotherapy.

AB - Kumar et al. report a previously unappreciated level of metabolic zonation within glioblastoma tumors dictated by the relative distance from blood vessels. This metabolic zonation leads to position-dependent functional heterogeneity. Proximity to perfused vessels endows a “privileged” perivascular tier with a distinctive mTOR-dominated anabolic metabolism, enhanced cancer aggressiveness, and superior resistance to chemo- and radiotherapy.

KW - blood vessels

KW - glioblastoma

KW - mTOR pathway

KW - metabolic compartmentalization

KW - tumor heterogeneity

KW - tumor microenvironment

KW - tumor vasculature

UR - http://www.scopus.com/inward/record.url?scp=85067351666&partnerID=8YFLogxK

U2 - https://doi.org/10.1016/j.cmet.2019.04.003

DO - https://doi.org/10.1016/j.cmet.2019.04.003

M3 - مقالة

C2 - 31056286

SN - 1550-4131

VL - 30

SP - 201-211.e6

JO - Cell Metabolism

JF - Cell Metabolism

IS - 1

ER -

Intra-Tumoral Metabolic Zonation and Resultant Phenotypic Diversification Are Dictated by Blood Vessel Proximity

Abstract

Keywords

All Science Journal Classification (ASJC) codes

UN SDGs

Access to Document

Other files and links

Fingerprint

Cite this