Intimate host attachment: Enteropathogenic and enterohaemorrhagic Escherichia coli

Yushuan Lai, Ilan Rosenshine, John M. Leong, Gad Frankel

Research output: Contribution to journalReview articlepeer-review

Abstract

Summary: Enteropathogenic and enterohaemorrhagic Escherichia coli use a novel infection strategy to colonize the gut epithelium, involving translocation of their own receptor, Tir, via a type III secretion system and subsequent formation of attaching and effecting (A/E) lesions. Following integration into the host cell plasma membrane of cultured cells, and clustering by the outer membrane adhesin intimin, Tir triggers multiple actin polymerization pathways involving host and bacterial adaptor proteins that converge on the host Arp2/3 actin nucleator. Although initially thought to be involved in A/E lesion formation, recent data have shown that the known Tir-induced actin polymerization pathways are dispensable for this activity, but can play other major roles in colonization efficiency, in vivo fitness and systemic disease. In this review we summarize the roadmap leading from the discovery of Tir, through the different actin polymerization pathways it triggers, to our current understanding of their physiological functions.

Original languageAmerican English
Pages (from-to)1796-1808
Number of pages13
JournalCellular Microbiology
Volume15
Issue number11
DOIs
StatePublished - Nov 2013

All Science Journal Classification (ASJC) codes

  • Microbiology
  • Immunology
  • Virology

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