Abstract
Background: Diabetes mellitus is associated with a more severe course of coronavirus disease 2019 (COVID-19). The severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) utilizes angiotensin-converting enzyme II (ACE2) receptor for host cell entry. We aimed to assess the interactions between antihyperglycemic drugs and the renin-angiotensin system (RAS) and their putative roles in COVID-19. Methods: A literature search was performed using Pubmed to review the interrelationships between hyperglycemia, RAS and COVID-19, and the effects of antihyperglycemic medications. Results: The RAS has an essential role in glucose homeostasis and may have a role in COVID-19-induced lung injury. Some antihyperglycemic medications modulate RAS and might hypothetically alleviate the deleterious effect of angiotensin II on lung injury. Furthermore, most antihyperglycemic medications showed anti-inflammatory effects in animal models of lung injury. Conclusions: Some antihyperglycemic medications might have protective effects against COVID-19-induced lung injury. Early insulin therapy seems very promising in alleviating lung injury.
| Original language | English |
|---|---|
| Pages (from-to) | 509-512 |
| Number of pages | 4 |
| Journal | Diabetes and Metabolic Syndrome: Clinical Research and Reviews |
| Volume | 14 |
| Issue number | 4 |
| DOIs | |
| State | Published - 11 May 2020 |
| Externally published | Yes |
Keywords
- ACE2
- Angiotensin-Converting Enzyme Inhibitors/therapeutic use
- Betacoronavirus/pathogenicity
- COVID-19
- Coronavirus Infections/complications
- Diabetes mellitus
- Glucose-lowering medications
- Host-Pathogen Interactions/drug effects
- Humans
- Hypoglycemic Agents/therapeutic use
- Insulin therapy
- Lung Diseases/drug therapy
- Pandemics
- Pneumonia, Viral/complications
- Renin-Angiotensin System/drug effects
- SARS-CoV-2
All Science Journal Classification (ASJC) codes
- Internal Medicine
- Endocrinology, Diabetes and Metabolism
