TY - GEN
T1 - Intelligent multi-sensor arrays for next generation diagnostic biodevices
AU - Ben-Yoav, Hadar
N1 - Publisher Copyright: Copyright © 2018 by SCITEPRESS – Science and Technology Publications, Lda. All rights reserved
PY - 2018/1/1
Y1 - 2018/1/1
N2 - Redox molecules play an essential role in many biological pathways, including energy metabolism, biosynthesis, and cell respiration. Moreover, a specific spectrum of redox molecules (comprising their type, concentration, and redox state) is involved in the development of diseases, including cancer. Thus, profiling the redox spectrum in the body is highly beneficial for a wide range of biomedical applications, from in vivo diagnostics to in situ monitoring of cell metabolism. Yet, the fundamental challenge lies within the ability to efficiently extract and analyze physiologically and medically relevant information from redox molecules in biofluids. This paper will discuss the advantageous approach to rapidly and continuously monitor redox molecules in biofluids using electrochemical lab-on-a-chip biodevices. The current approaches will be discussed to selectively measure redox molecules from biofluids without diminishing the rapid and continuous monitoring capabilities of these translational biodevices, i.e., by simultaneously analyzing multiple diagnostic redox biomarkers in a stand-alone operation, without any sample pretreatment or elimination of other interfering molecules. Then, the promising approach of using intelligent multi-sensor arrays will be highlighted for the rapid detection of a spectrum of redox molecules and the current challenges impeding their important utilization for next generation biomedical diagnostic devices.
AB - Redox molecules play an essential role in many biological pathways, including energy metabolism, biosynthesis, and cell respiration. Moreover, a specific spectrum of redox molecules (comprising their type, concentration, and redox state) is involved in the development of diseases, including cancer. Thus, profiling the redox spectrum in the body is highly beneficial for a wide range of biomedical applications, from in vivo diagnostics to in situ monitoring of cell metabolism. Yet, the fundamental challenge lies within the ability to efficiently extract and analyze physiologically and medically relevant information from redox molecules in biofluids. This paper will discuss the advantageous approach to rapidly and continuously monitor redox molecules in biofluids using electrochemical lab-on-a-chip biodevices. The current approaches will be discussed to selectively measure redox molecules from biofluids without diminishing the rapid and continuous monitoring capabilities of these translational biodevices, i.e., by simultaneously analyzing multiple diagnostic redox biomarkers in a stand-alone operation, without any sample pretreatment or elimination of other interfering molecules. Then, the promising approach of using intelligent multi-sensor arrays will be highlighted for the rapid detection of a spectrum of redox molecules and the current challenges impeding their important utilization for next generation biomedical diagnostic devices.
KW - Biomedical Diagnostics
KW - Chemometrics
KW - Electrochemical Sensors
KW - Intelligent Sensors
KW - Lab-on-a-Chip
KW - Redox
UR - http://www.scopus.com/inward/record.url?scp=85051719786&partnerID=8YFLogxK
U2 - https://doi.org/10.5220/0006653602360240
DO - https://doi.org/10.5220/0006653602360240
M3 - Conference contribution
T3 - BIODEVICES 2018 - 11th International Conference on Biomedical Electronics and Devices, Proceedings; Part of 11th International Joint Conference on Biomedical Engineering Systems and Technologies, BIOSTEC 2018
SP - 236
EP - 240
BT - BIODEVICES 2018 - 11th International Conference on Biomedical Electronics and Devices, Proceedings; Part of 11th International Joint Conference on Biomedical Engineering Systems and Technologies, BIOSTEC 2018
A2 - Cliquet, Alberto
A2 - Gamboa, Hugo
A2 - Fred, Ana
A2 - Bermudez i Badia, Sergi
T2 - 11th International Conference on Biomedical Electronics and Devices, BIODEVICES 2018 - Part of 11th International Joint Conference on Biomedical Engineering Systems and Technologies, BIOSTEC 2018
Y2 - 19 January 2018 through 21 January 2018
ER -