Integrative structural modeling with small angle X-ray scattering profiles

Dina Schneidman-Duhovny, Seung Joong Kim, Andrej Sali

Research output: Contribution to journalReview articlepeer-review

Abstract

Recent technological advances enabled high-throughput collection of Small Angle X-ray Scattering (SAXS) profiles of biological macromolecules. Thus, computational methods for integrating SAXS profiles into structural modeling are needed more than ever. Here, we review specifically the use of SAXS profiles for the structural modeling of proteins, nucleic acids, and their complexes. First, the approaches for computing theoretical SAXS profiles from structures are presented. Second, computational methods for predicting protein structures, dynamics of proteins in solution, and assembly structures are covered. Third, we discuss the use of SAXS profiles in integrative structure modeling approaches that depend simultaneously on several data types.

Original languageAmerican English
Article number17
JournalBmc Structural Biology
Volume12
DOIs
StatePublished - 2012
Externally publishedYes

Keywords

  • Integrative modeling
  • Macromolecular assembly
  • Protein structure prediction
  • Small Angle X-ray Scattering (SAXS)

All Science Journal Classification (ASJC) codes

  • Structural Biology

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