@inbook{adc0775520d048b59d75898ad80345a1,
title = "Integration of plant metabolomics data with metabolic networks: Progresses and challenges",
abstract = "In the last decade, plant genome-scale modeling has developed rapidly and modeling efforts have advanced from representing metabolic behavior of plant heterotrophic cell suspensions to studying the complex interplay of cell types, tissues, and organs. A crucial driving force for such developments is the availability and integration of “omics” data (e.g., transcriptomics, proteomics, and metabolomics) which enable the reconstruction, extraction, and application of context-specific metabolic networks. In this chapter, we demonstrate a workflow to integrate gas chromatography coupled to mass spectrometry (GC-MS)-based metabolomics data of tomato fruit pericarp (flesh) tissue, at five developmental stages, with a genome-scale reconstruction of tomato metabolism. This method allows for the extraction of context-specific networks reflecting changing activities of metabolic pathways throughout fruit development and maturation.",
author = "Nadine T{\"o}pfer and Seaver, {Samuel M.D.} and Asaph Aharoni",
note = "N. T{\"o}pfer and A. Aharoni thank the Adelis Foundation, the Leona M. and Harry B. Helmsley Charitable Trust; the Jeanne and Joseph Nissim Foundation for Life Sciences; and especially the Tom and Sondra Rykoff Family Foundation Research for supporting the A. Aharoni lab activity. A. Aharoni is the incumbent of the Peter J. Cohn Professorial Chair. S.M.D. Seaver was supported by National Science Foundation Grant Number IOS-1444202 and by the Office of Science, Office of Biological and Environmental Research, of the US Department of Energy under contract number DE-ACO2-06CH11357, as part of the DOE Systems Biology Knowledgebase.",
year = "2018",
month = may,
day = "15",
doi = "https://doi.org/10.1007/978-1-4939-7819-9_21",
language = "الإنجليزيّة",
isbn = "978-1-4939-7818-2",
series = "Methods in Molecular Biology",
publisher = "Humana Press",
pages = "297--310",
editor = "Carla Ant{\'o}nio",
booktitle = "Plant Metabolomics",
address = "الولايات المتّحدة",
}