Insulin is expressed by enteroendocrine cells during human fetal development

Adi Egozi; Dhana Llivichuzhca-Loja; Blake T McCourt; Keren Bahar Halpern; Lydia Farack; Xiaojing An; Fujing Wang; Kong Chen; Liza Konnikova; Shalev Itzkovitz

doi:10.1038/s41591-021-01586-1

Insulin is expressed by enteroendocrine cells during human fetal development

Adi Egozi, Dhana Llivichuzhca-Loja, Blake T McCourt, Keren Bahar Halpern, Lydia Farack, Xiaojing An, Fujing Wang, Kong Chen, Liza Konnikova, Shalev Itzkovitz

Department of Molecular Cell Biology

Weizmann Institute of Science

Research output: Contribution to journal › Article › peer-review

Abstract

Generation of beta cells via transdifferentiation of other cell types is a promising avenue for the treatment of diabetes. Here we reconstruct a single-cell atlas of the human fetal and neonatal small intestine. We identify a subset of fetal enteroendocrine K/L cells that express high levels of insulin and other beta cell genes. Our findings highlight a potential extra-pancreatic source of beta cells and expose its molecular blueprint.

Original language	English
Pages (from-to)	2104-2107
Number of pages	4
Journal	Nature Medicine
Volume	27
Issue number	12
DOIs	https://doi.org/10.1038/s41591-021-01586-1
State	Published - Dec 2021

All Science Journal Classification (ASJC) codes

General Biochemistry,Genetics and Molecular Biology

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10.1038/s41591-021-01586-1

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abstract = "Generation of beta cells via transdifferentiation of other cell types is a promising avenue for the treatment of diabetes. Here we reconstruct a single-cell atlas of the human fetal and neonatal small intestine. We identify a subset of fetal enteroendocrine K/L cells that express high levels of insulin and other beta cell genes. Our findings highlight a potential extra-pancreatic source of beta cells and expose its molecular blueprint.",

author = "Adi Egozi and Dhana Llivichuzhca-Loja and McCourt, {Blake T} and {Bahar Halpern}, Keren and Lydia Farack and Xiaojing An and Fujing Wang and Kong Chen and Liza Konnikova and Shalev Itzkovitz",

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doi = "10.1038/s41591-021-01586-1",

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AU - Egozi, Adi

AU - Llivichuzhca-Loja, Dhana

AU - McCourt, Blake T

AU - Bahar Halpern, Keren

AU - Farack, Lydia

AU - An, Xiaojing

AU - Wang, Fujing

AU - Chen, Kong

AU - Konnikova, Liza

AU - Itzkovitz, Shalev

PY - 2021/12

Y1 - 2021/12

N2 - Generation of beta cells via transdifferentiation of other cell types is a promising avenue for the treatment of diabetes. Here we reconstruct a single-cell atlas of the human fetal and neonatal small intestine. We identify a subset of fetal enteroendocrine K/L cells that express high levels of insulin and other beta cell genes. Our findings highlight a potential extra-pancreatic source of beta cells and expose its molecular blueprint.

AB - Generation of beta cells via transdifferentiation of other cell types is a promising avenue for the treatment of diabetes. Here we reconstruct a single-cell atlas of the human fetal and neonatal small intestine. We identify a subset of fetal enteroendocrine K/L cells that express high levels of insulin and other beta cell genes. Our findings highlight a potential extra-pancreatic source of beta cells and expose its molecular blueprint.

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U2 - 10.1038/s41591-021-01586-1

DO - 10.1038/s41591-021-01586-1

M3 - مقالة

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SP - 2104

EP - 2107

JO - Nature Medicine

JF - Nature Medicine

IS - 12

ER -

Insulin is expressed by enteroendocrine cells during human fetal development

Abstract

All Science Journal Classification (ASJC) codes

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