Insulin fibrillation control by specific zinc binding sites

Shira Ben-Shushan, Yifat Miller

Research output: Contribution to journalArticlepeer-review


Herein, we present for the first time a study that identifies the morphology of full-length insulin fibrils in the absence and in the presence of Zn2+ ions. Different possible metal binding sites were probed within insulin fibrils at the molecular level. The effects of Zn2+ ions on the fibrillation of insulin are determined for each specific Zn2+-binding site on the characterization and stabilization of the fibrils. Our findings are expected to initiate future studies to investigate the functions of unique insulin fibrils that bind the Zn2+ ions.

Original languageAmerican English
Pages (from-to)5251-5259
Number of pages9
JournalInorganic Chemistry Frontiers
Issue number24
StatePublished - 21 Dec 2021

All Science Journal Classification (ASJC) codes

  • Inorganic Chemistry


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