Insights into the co-evolution of epithelial cells and fibroblasts in the esophageal tumor microenvironment

Hagar Lavon; Ruth Scherz-Shouval

doi:10.1016/j.ccell.2023.03.020

Insights into the co-evolution of epithelial cells and fibroblasts in the esophageal tumor microenvironment

Hagar Lavon, Ruth Scherz-Shouval

Department of Biomolecular Sciences

Weizmann Institute of Science

Research output: Contribution to journal › Editorial › peer-review

Abstract

Cancer-associated fibroblasts (CAFs) are recruited and rewired by cancer cells to become protumorigenic. The molecular mechanisms underlying this crosstalk in esophageal cancer are completely unknown. Chen et al. discover that premalignant epithelial cells of the esophagus rewire normal resident fibroblasts into CAFs through the downregulation of ANXA1-FRP2 signaling.

Original language	English
Pages (from-to)	826-828
Number of pages	3
Journal	Cancer Cell
Volume	41
Issue number	5
DOIs	https://doi.org/10.1016/j.ccell.2023.03.020
State	Published - 8 May 2023

All Science Journal Classification (ASJC) codes

Oncology
Cancer Research

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10.1016/j.ccell.2023.03.020

Cite this

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title = "Insights into the co-evolution of epithelial cells and fibroblasts in the esophageal tumor microenvironment",

abstract = "Cancer-associated fibroblasts (CAFs) are recruited and rewired by cancer cells to become protumorigenic. The molecular mechanisms underlying this crosstalk in esophageal cancer are completely unknown. Chen et al. discover that premalignant epithelial cells of the esophagus rewire normal resident fibroblasts into CAFs through the downregulation of ANXA1-FRP2 signaling.",

author = "Hagar Lavon and Ruth Scherz-Shouval",

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year = "2023",

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doi = "10.1016/j.ccell.2023.03.020",

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AU - Lavon, Hagar

AU - Scherz-Shouval, Ruth

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N2 - Cancer-associated fibroblasts (CAFs) are recruited and rewired by cancer cells to become protumorigenic. The molecular mechanisms underlying this crosstalk in esophageal cancer are completely unknown. Chen et al. discover that premalignant epithelial cells of the esophagus rewire normal resident fibroblasts into CAFs through the downregulation of ANXA1-FRP2 signaling.

AB - Cancer-associated fibroblasts (CAFs) are recruited and rewired by cancer cells to become protumorigenic. The molecular mechanisms underlying this crosstalk in esophageal cancer are completely unknown. Chen et al. discover that premalignant epithelial cells of the esophagus rewire normal resident fibroblasts into CAFs through the downregulation of ANXA1-FRP2 signaling.

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U2 - 10.1016/j.ccell.2023.03.020

DO - 10.1016/j.ccell.2023.03.020

M3 - كلمة العدد

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SN - 1535-6108

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JO - Cancer Cell

JF - Cancer Cell

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ER -

Insights into the co-evolution of epithelial cells and fibroblasts in the esophageal tumor microenvironment

Abstract

All Science Journal Classification (ASJC) codes

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