Inside Cover: Selective Inhibition of Aggregation and Toxicity of a Tau‐Derived Peptide using Its Glycosylated Analogues (Chem. Eur. J. 17/2016)

Amyloid formation is attenuated by a single glycan unit. Using β-O-linked glycosylated variants of the Tau-derived hexapeptide motif, VQIVYK, which served as a simplified amyloid model scaffold, it is demonstrated that amyloid formation and toxicity can be strongly attenuated by a glycan unit, depending on the nature of the glycan itself. Moreover, the glycosylated peptides inhibit aggregation of the corresponding non-modified amyloid scaffold. More information can be found in the Full Paper by D. Segal, S. Rahimipour, E. Gazit et al. on page 5945 ff.