Inhibitors of receptor tyrosine kinases and methods of use thereof

Joseph Schlessinger; Irit Lax; Satoru Yuzawa; Yarden Opatowsky; Yan Yang

Inhibitors of receptor tyrosine kinases and methods of use thereof

Joseph Schlessinger (Inventor), Irit Lax (Inventor), Satoru Yuzawa (Inventor), Yarden Opatowsky (Inventor), Yan Yang (Inventor)

The Mina and Everard Goodman Faculty of Life Sciences

Bar-Ilan University

Research output: Patent

Abstract

The present invention provides moieties that bind to an Ig-like domain, e.g., D4 or D5, of a human receptor tyrosine kinase, e.g., the human Kit RTK or the PDGFR RTK, or the D7 domain of a type V receptor tyrosine kinase wherein the moieties lock the ectodomain of the receptor tyrosine kinase in an inactive state thereby antagonizing the activity of the receptor tyrosine kinase.

Original language	English
Patent number	US9273134B2
State	Published - 1 Mar 2016

Cite this

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title = "Inhibitors of receptor tyrosine kinases and methods of use thereof",

abstract = "The present invention provides moieties that bind to an Ig-like domain, e.g., D4 or D5, of a human receptor tyrosine kinase, e.g., the human Kit RTK or the PDGFR RTK, or the D7 domain of a type V receptor tyrosine kinase wherein the moieties lock the ectodomain of the receptor tyrosine kinase in an inactive state thereby antagonizing the activity of the receptor tyrosine kinase.",

author = "Joseph Schlessinger and Irit Lax and Satoru Yuzawa and Yarden Opatowsky and Yan Yang",

note = "US Patent 9,273,134; US9273134B2",

year = "2016",

month = mar,

day = "1",

language = "الإنجليزيّة",

type = "Patent",

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TY - PAT

T1 - Inhibitors of receptor tyrosine kinases and methods of use thereof

AU - Schlessinger, Joseph

AU - Lax, Irit

AU - Yuzawa, Satoru

AU - Opatowsky, Yarden

AU - Yang, Yan

N1 - US Patent 9,273,134

PY - 2016/3/1

Y1 - 2016/3/1

N2 - The present invention provides moieties that bind to an Ig-like domain, e.g., D4 or D5, of a human receptor tyrosine kinase, e.g., the human Kit RTK or the PDGFR RTK, or the D7 domain of a type V receptor tyrosine kinase wherein the moieties lock the ectodomain of the receptor tyrosine kinase in an inactive state thereby antagonizing the activity of the receptor tyrosine kinase.

AB - The present invention provides moieties that bind to an Ig-like domain, e.g., D4 or D5, of a human receptor tyrosine kinase, e.g., the human Kit RTK or the PDGFR RTK, or the D7 domain of a type V receptor tyrosine kinase wherein the moieties lock the ectodomain of the receptor tyrosine kinase in an inactive state thereby antagonizing the activity of the receptor tyrosine kinase.

UR - https://patents.google.com/patent/US9273134B2/en

M3 - براءة الإختراع

M1 - US9273134B2

ER -

Inhibitors of receptor tyrosine kinases and methods of use thereof

Abstract

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