@inproceedings{dd6130f0256b46e0bdef74ff2715d69f,
title = "Infrared surface plasmon spectroscopy and biosensing",
abstract = "The cell morphology is a valuable indicator of the physical condition and general status of the cell. Here we demonstrate a methodology for noninvasive biosensing of adherent living cells. Our method is based on infrared reflection spectroscopy of living cells cultured on thin Au film. To characterize cell morphology we utilized the unique properties of the infrared surface plasmon (λ=1-3 μm) and infrared guided wave that travel inside the cell monolayer. We demonstrate that our method enables monitoring of submicron variations in cell morphology in real-time and in a labelfree manner. In addition to morphological characterization, our method allows investigation of chemical composition and molecular structure of cells through infrared absorption spectroscopy analysis.",
keywords = "Biosensor, Evanescent Waves, Infrared spectroscopy, Label-free, Living Cells, Noninvasive method, Surface Plasmon",
author = "Victor Yashunsky and Alexander Zilbershtein and Vladislav Lirtsman and Tal Marciano and Benjamin Aroeti and Michael Golosovsky and Dan Davidov",
year = "2012",
month = mar,
day = "2",
doi = "https://doi.org/10.1117/12.907255",
language = "American English",
isbn = "9780819488770",
series = "Progress in Biomedical Optics and Imaging - Proceedings of SPIE",
booktitle = "Plasmonics in Biology and Medicine IX",
note = "Plasmonics in Biology and Medicine IX ; Conference date: 22-01-2012 Through 24-01-2012",
}