Inflammatory networks underlying colorectal cancer

Audrey Lasry; Adar Zinger; Yinon Ben-Neriah

doi:https://doi.org/10.1038/ni.3384

Inflammatory networks underlying colorectal cancer

Audrey Lasry, Adar Zinger, Yinon Ben-Neriah

Department of Immunology and Cancer Research

The Hebrew University of Jerusalem

Research output: Contribution to journal › Review article › peer-review

Abstract

Inflammation is emerging as one of the hallmarks of cancer, yet its role in most tumors remains unclear. Whereas a minority of solid tumors are associated with overt inflammation, long-term treatment with non-steroidal anti-inflammatory drugs is remarkably effective in reducing cancer rate and death. This indicates that inflammation might have many as-yet-unrecognized facets, among which an indolent course might be far more prevalent than previously appreciated. In this Review, we explore the various inflammatory processes underlying the development and progression of colorectal cancer and discuss anti-inflammatory means for its prevention and treatment.

Original language	English
Pages (from-to)	230-240
Number of pages	11
Journal	Nature Immunology
Volume	17
Issue number	3
DOIs	https://doi.org/10.1038/ni.3384
State	Published - 16 Feb 2016

All Science Journal Classification (ASJC) codes

Immunology and Allergy
Immunology

UN SDGs

This output contributes to the following UN Sustainable Development Goals (SDGs)

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https://doi.org/10.1038/ni.3384

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title = "Inflammatory networks underlying colorectal cancer",

abstract = "Inflammation is emerging as one of the hallmarks of cancer, yet its role in most tumors remains unclear. Whereas a minority of solid tumors are associated with overt inflammation, long-term treatment with non-steroidal anti-inflammatory drugs is remarkably effective in reducing cancer rate and death. This indicates that inflammation might have many as-yet-unrecognized facets, among which an indolent course might be far more prevalent than previously appreciated. In this Review, we explore the various inflammatory processes underlying the development and progression of colorectal cancer and discuss anti-inflammatory means for its prevention and treatment.",

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AB - Inflammation is emerging as one of the hallmarks of cancer, yet its role in most tumors remains unclear. Whereas a minority of solid tumors are associated with overt inflammation, long-term treatment with non-steroidal anti-inflammatory drugs is remarkably effective in reducing cancer rate and death. This indicates that inflammation might have many as-yet-unrecognized facets, among which an indolent course might be far more prevalent than previously appreciated. In this Review, we explore the various inflammatory processes underlying the development and progression of colorectal cancer and discuss anti-inflammatory means for its prevention and treatment.

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Inflammatory networks underlying colorectal cancer

Abstract

All Science Journal Classification (ASJC) codes

UN SDGs

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